Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Department of Neurology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Neuroscience. 2019 Aug 10;413:308-316. doi: 10.1016/j.neuroscience.2019.05.015. Epub 2019 May 16.
Parkinson's disease (PD) is a common movement disorder. Alpha-synuclein (α-synuclein) plays a critical role in PD. In this study, we evaluated the level of central nervous system (CNS)-derived exosomal α-synuclein in serum, which may be regarded as a specific peripheral biomarker for PD. We recruited patients with PD in the early stage along with essential tremor (ET), and we recruited age- and gender-matched healthy subjects as healthy controls (HC). We divided patients with PD into the tremor-dominant (TD) group and the non-tremor-dominant (NTD) group. We evaluated the levels of α-synuclein in CNS-derived exosomes in serum samples. As a result, there was a significant difference between four groups (p<0.05). This level was lower in the PD group than in the ET and HC groups (p<0.05). Among the PD group, this level was lower in the NTD group than in the TD group (p<0.05). Furthermore, the performance of serum CNS-derived exosomal α-synuclein was found to moderately aid in PD diagnosis (AUC=0.675, p<0.05) and had a potential to diagnose NTD (AUC=0.761, p<0.05). Therefore, CNS-derived exosomal α-synuclein in the serum may be regarded as a biomarker to identify PD from ET and HC in the early stage. It may also be used to identify different motor types in PD. The pathogenesis of PD in different motor types may be different, which needs further research.
帕金森病（PD）是一种常见的运动障碍。α-突触核蛋白（α-synuclein）在 PD 中起着关键作用。在这项研究中，我们评估了血清中中枢神经系统（CNS）衍生的细胞外体α-突触核蛋白的水平，它可能被视为 PD 的一种特定的外周生物标志物。我们招募了早期 PD 患者以及特发性震颤（ET）患者，并招募了年龄和性别匹配的健康受试者作为健康对照组（HC）。我们将 PD 患者分为震颤为主（TD）组和非震颤为主（NTD）组。我们评估了血清样本中 CNS 衍生的细胞外体α-突触核蛋白的水平。结果，四个组之间存在显著差异（p<0.05）。PD 组的水平低于 ET 组和 HC 组（p<0.05）。在 PD 组中，NTD 组的水平低于 TD 组（p<0.05）。此外，发现血清 CNS 衍生的细胞外体α-突触核蛋白的表现有助于中度 PD 诊断（AUC=0.675，p<0.05），并具有诊断 NTD 的潜力（AUC=0.761，p<0.05）。因此，血清中的 CNS 衍生的细胞外体α-突触核蛋白可能被视为一种生物标志物，可用于在早期将 PD 与 ET 和 HC 区分开来。它也可用于识别 PD 中的不同运动类型。不同运动类型的 PD 的发病机制可能不同，这需要进一步研究。
