This study compared the dosimetric and radiobiological parameters of prostate volumetric modulated arc therapy (VMAT) plans using different prescriptions optimized by the photon optimization (PO) and progressive resolution optimization (PRO) algorithm. A total of 20 prostate patients were selected retrospectively and divided into 2 groups of VMAT plans using prescriptions of 60 Gy/20 fx and 79 Gy/38 fx. Inverse treatment planning optimized by the PO and PRO algorithm based on the dual-arc technique was carried out by the Eclipse treatment planning system. The maximum dose, minimum dose, mean dose, dose-volume points, and dose-volume indices of the targets and organs at risk (OAR) were calculated from the plans. In addition, radiobiological parameters such as tumor control probability (TCP), normal tissue complication probability (NTCP), and equivalent uniform dose (EUD) of the targets and OAR were determined based on their dose-volume histograms (DVHs). A paired Student's t-test was carried out to compare the difference between mean dose-volume points, radiobiological parameters, and dose-volume indices. Two-tailed p < 0.05 was defined as having statistical difference. For prostate VMAT plans optimized by the PO algorithm, equal or slightly larger mean dose and TCP of the PTV (1% for 60 Gy/20 fx and 0.2% for 78 Gy/39 fx) were found by comparing to the PRO. These were followed by finding the slightly larger conformity index (CI; 0.927 vs 0.895 and 0.910 vs 0.904), larger or equal homogeneity index (HI; 0.054 vs 0.052 and 0.058 vs 0.058), and smaller gradient index (GI; 1.366 vs 2.288 and 1.585 vs 1.742) of the PTV using plans optimized by the PO vs PRO using prescriptions of 60 Gy/20 fx and 78 Gy/39 fx. For the OAR, we found that the mean doses, NTCPs, and EUDs of the rectum, bladder, and femur were slightly larger for plans optimized by the PO algorithm compared to the PRO, though both optimization algorithms satisfied all the dose-volume criteria and objectives in the inverse planning. Both the PO and PRO algorithm can generate prostate VMAT plans fulfilling the required dose-volume criteria. It is concluded that plans optimized by the PO algorithm can produce prostate plan with very similar quality compared to PRO.