新型心肌 PET/CT 受体显像及潜在治疗靶点。
Novel Myocardial PET/CT Receptor Imaging and Potential Therapeutic Targets.
机构信息
Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, Washington University in St. Louis, 510 S. Kingshighway Boulevard, Campus Box 8223, St. Louis, MO, 63110, USA.
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
出版信息
Curr Cardiol Rep. 2019 May 18;21(7):55. doi: 10.1007/s11886-019-1148-2.
PURPOSE OF THE REVIEW
Activation of myocardial cannabinoid type 1 receptors (CB1-R) and/or angiotensin II type 1 receptors (AT1-R) likely plays an important mechanistic role in determining the left-ventricular remodeling process in systolic heart failure. We provide an overview on novel radiotracer probes and positron emission tomography (PET)/computed tomography (CT) imaging to noninvasively probe the expression of myocardial CB1-R and/or AT1-R.
RECENT FINDINGS
Recent translational investigations have demonstrated the feasibility of C-OMAR or C-KR31173 and PET/CT to image and quantify myocardial CB1-R and/or AT1-R expression, respectively. There is an increasing understanding of the mechanisms of activated myocardial CB1-R and/or AT1-R to influence the left-ventricular remodeling process in systolic heart failure in different disease entities. The review summarizes contributions of PET to image myocardial CB1-R and AT1-R expression that may have the potential to serve as a target to tailor preventive medical care in the individual patient.
综述目的
心肌大麻素 1 型受体（CB1-R）和/或血管紧张素 II 型 1 型受体（AT1-R）的激活可能在确定收缩性心力衰竭的左心室重构过程中起着重要的机制作用。我们提供了一种新型放射性示踪探针和正电子发射断层扫描（PET）/计算机断层扫描（CT）成像的概述，以非侵入性地探测心肌 CB1-R 和/或 AT1-R 的表达。
最新发现
最近的转化研究已经证明了 C-OMAR 或 C-KR31173 以及 PET/CT 分别用于成像和定量心肌 CB1-R 和/或 AT1-R 表达的可行性。人们越来越了解激活的心肌 CB1-R 和/或 AT1-R 影响收缩性心力衰竭中左心室重构过程的机制，在不同的疾病实体中。该综述总结了 PET 对心肌 CB1-R 和 AT1-R 表达成像的贡献，这些贡献可能有潜力作为针对个体患者进行预防性医疗的靶点。
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