Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Int J Hematol. 2019 Sep;110(3):375-380. doi: 10.1007/s12185-019-02656-4. Epub 2019 May 18.
The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.
由于人口老龄化，多发性原发性恶性肿瘤（MPMN）的发病率正在上升。由于缺乏治疗 MPMN 的共识指南，因此治疗策略是根据每位患者的疾病状况来确定的。在本报告中，我们描述了一例滤泡淋巴瘤（FL）1 级的 MPMN，在同期卵巢癌的辅助化疗期间转化为双打击淋巴瘤。一位 64 岁女性因分期剖腹术和淋巴结活检而被诊断为 MPMN 的 FL 和子宫内膜样癌。她接受了四个周期的辅助化疗（卡铂和紫杉醇）用于子宫内膜样癌，但在化疗期间，FL 1 级转化为双打击淋巴瘤。我们推测，本例中子宫内膜样癌的辅助化疗可能触发了 FL 的转化。
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