Matsushima Y, Hazama H, Kishimoto A
Jpn J Psychiatry Neurol. 1986 Dec;40(4):625-30. doi: 10.1111/j.1440-1819.1986.tb03177.x.
The chromosomal aberrations of 13 patients who had received continuous lithium therapy for affective disorders were examined. Healthy college women were used as controls. There was a high frequency in gaps among the patients compared with the controls, but there was no significant difference between them. Although there was a significant relationship between the age of patients and the incidence of abnormal cells, there was no relationship between the duration of lithium therapy and the incidence of abnormal cells. These results suggest that lithium carbonate has neither the suppression effect of chromosomal repair mechanisms nor mutagenic activity. In order to discuss the teratogenicity of lithium salts on human beings, it seems necessary to conduct chromosome examinations of babies born to lithium-treated women.
对13名因情感障碍接受持续锂盐治疗的患者的染色体畸变情况进行了检查。选取健康的大学女生作为对照。与对照组相比，患者组的染色体间隙频率较高，但两组之间无显著差异。虽然患者年龄与异常细胞发生率之间存在显著关系，但锂盐治疗时长与异常细胞发生率之间并无关联。这些结果表明，碳酸锂既没有抑制染色体修复机制的作用，也没有诱变活性。为了探讨锂盐对人类的致畸性，似乎有必要对接受锂盐治疗的女性所生婴儿进行染色体检查。
