A suspected case of late-onset sodium-valproate-induced hepatic failure.
作者信息
van Egmond H, Degomme P, de Simpel H, Dierick A M, Roels H
出版信息
Neuropediatrics. 1987 May;18(2):96-8. doi: 10.1055/s-2008-1052461.
PMID:3110642
Abstract
A 15-year-old boy was under anti-epileptic medication (diphenylhydantoine, phenobarbital and Na valproate) for more than five years. He was admitted in cerebral coma and died after 24 hours. The histological findings suggest a valproate induced liver toxicity. This long interval between start of treatment and a possibly related hepatic failure has not been described.
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