van Egmond H, Degomme P, de Simpel H, Dierick A M, Roels H
Neuropediatrics. 1987 May;18(2):96-8. doi: 10.1055/s-2008-1052461.
A 15-year-old boy was under anti-epileptic medication (diphenylhydantoine, phenobarbital and Na valproate) for more than five years. He was admitted in cerebral coma and died after 24 hours. The histological findings suggest a valproate induced liver toxicity. This long interval between start of treatment and a possibly related hepatic failure has not been described.
