所有人都来处理 DEK。
All hands on DEK.
出版信息
J Clin Invest. 2019 May 20;129(6):2205-2206. doi: 10.1172/JCI128986.
Abstract
In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted by macrophages and other cells, but no function has been attached to secreted DEK. Capitano et al. showed that extracellular DEK activates signaling through the CXCL2 receptor, which in turn enhances the proliferation of hematopoietic stem cells and decreases hematopoietic progenitor cell numbers both in vivo and in vitro. These results offer the opportunity to expand transplantable stem cells to improve outcomes in patients undergoing bone marrow transplant.
摘要
在本期 JCI 中，Capitano 等人证明了 DNA 结合染色质因子 DEK 的分泌形式可调节造血。已知 DEK 可被巨噬细胞和其他细胞分泌，但尚未确定分泌型 DEK 的功能。Capitano 等人表明，细胞外 DEK 通过 CXCL2 受体激活信号转导，进而增强体内和体外造血干细胞的增殖，并减少造血祖细胞数量。这些结果为扩大可移植干细胞提供了机会，以改善接受骨髓移植的患者的预后。
相似文献
1
All hands on DEK.所有人都来处理 DEK。
J Clin Invest. 2019 May 20;129(6):2205-2206. doi: 10.1172/JCI128986.
2
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.分泌核蛋白 DEK 通过 CXCR2 信号调节造血。
J Clin Invest. 2019 May 20;129(6):2555-2570. doi: 10.1172/JCI127460.
3
A role for intracellular and extracellular DEK in regulating hematopoiesis.细胞内和细胞外DEK在调节造血过程中的作用。
Curr Opin Hematol. 2017 Jul;24(4):300-306. doi: 10.1097/MOH.0000000000000344.
4
Concise review: role of DEK in stem/progenitor cell biology.简明综述：DEK 在干细胞/祖细胞生物学中的作用。
Stem Cells. 2013 Aug;31(8):1447-53. doi: 10.1002/stem.1443.
5
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.核 DEK 通过 NCoR1/HDAC3-Akt1/2-mTOR 轴来维持造血干细胞的潜能。
J Exp Med. 2021 May 3;218(5). doi: 10.1084/jem.20201974.
6
DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.DEK 调节造血干细胞植入和祖细胞增殖。
Stem Cells Dev. 2012 Jun 10;21(9):1449-54. doi: 10.1089/scd.2011.0451. Epub 2011 Oct 27.
7
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.DEK缺失诱导小鼠受限造血祖细胞的放射抗性。
Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27.
8
The Complexity of DEK Signaling in Cancer Progression.DEK 信号在癌症进展中的复杂性。
Curr Cancer Drug Targets. 2018;18(3):256-265. doi: 10.2174/1568009617666170522094730.
9
The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia.染色质结合蛋白 DEK 在造血和急性髓系白血病中的作用。
Exp Hematol. 2023 Jul;123:18-27. doi: 10.1016/j.exphem.2023.05.002. Epub 2023 May 10.
10
DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML).DEK癌基因在正常造血过程及急性髓系白血病（AML）中的表达。
Blood Cells Mol Dis. 2015 Jan;54(1):123-31. doi: 10.1016/j.bcmd.2014.07.009. Epub 2014 Aug 12.
引用本文的文献
1
DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.靶向DEK的适配体DTA-64通过抑制哮喘中TGF-β1/Smad、MAPK和PI3K信号通路减轻支气管上皮-间质转化介导的气道重塑。
J Cell Mol Med. 2020 Dec;24(23):13739-13750. doi: 10.1111/jcmm.15942. Epub 2020 Oct 30.
本文引用的文献
1
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.分泌核蛋白 DEK 通过 CXCR2 信号调节造血。
J Clin Invest. 2019 May 20;129(6):2555-2570. doi: 10.1172/JCI127460.
2
High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti-Tumor Necrosis Factor Therapy.血清中高水平的 DEK 自身抗体存在于多关节型幼年特发性关节炎患者中，以及在停止抗肿瘤坏死因子治疗后出现早期疾病复发的患者中。
Arthritis Rheumatol. 2018 Apr;70(4):594-605. doi: 10.1002/art.40404. Epub 2018 Feb 22.
3
High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair.高迁移率族蛋白 B1 通过炎症、先天和适应性免疫以及组织修复来协调对组织损伤的反应。
Immunol Rev. 2017 Nov;280(1):74-82. doi: 10.1111/imr.12601.
4
DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.靶向 DEK 的 DNA 适体作为治疗炎症性关节炎的药物。
Nat Commun. 2017 Feb 6;8:14252. doi: 10.1038/ncomms14252.
5
The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.DEK 癌蛋白是一种 Su(var)，对异染色质的完整性至关重要。
Genes Dev. 2011 Apr 1;25(7):673-8. doi: 10.1101/gad.2036411.
6
DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.DEK是细胞凋亡中的一种聚（ADP - 核糖）受体，并介导对基因毒性应激的抗性。
Mol Cell Biol. 2008 May;28(10):3245-57. doi: 10.1128/MCB.01921-07. Epub 2008 Mar 10.
7
The DEK nuclear autoantigen is a secreted chemotactic factor.DEK核自身抗原是一种分泌性趋化因子。
Mol Cell Biol. 2006 Dec;26(24):9484-96. doi: 10.1128/MCB.01030-06. Epub 2006 Oct 9.
8
The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.DEK蛋白——哺乳动物染色质中一种丰富且普遍存在的成分。
Gene. 2004 Dec 8;343(1):1-9. doi: 10.1016/j.gene.2004.08.029.
9
Dek-can rearrangement in translocation (6;9)(p23;q34).
Leukemia. 1992 Jun;6(6):489-94.
Zotero 插件