J Clin Invest. 2019 May 20;129(6):2205-2206. doi: 10.1172/JCI128986.
In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted by macrophages and other cells, but no function has been attached to secreted DEK. Capitano et al. showed that extracellular DEK activates signaling through the CXCL2 receptor, which in turn enhances the proliferation of hematopoietic stem cells and decreases hematopoietic progenitor cell numbers both in vivo and in vitro. These results offer the opportunity to expand transplantable stem cells to improve outcomes in patients undergoing bone marrow transplant.
在本期 JCI 中，Capitano 等人证明了 DNA 结合染色质因子 DEK 的分泌形式可调节造血。已知 DEK 可被巨噬细胞和其他细胞分泌，但尚未确定分泌型 DEK 的功能。Capitano 等人表明，细胞外 DEK 通过 CXCL2 受体激活信号转导，进而增强体内和体外造血干细胞的增殖，并减少造血祖细胞数量。这些结果为扩大可移植干细胞提供了机会，以改善接受骨髓移植的患者的预后。
