Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Org Biomol Chem. 2019 May 29;17(21):5258-5261. doi: 10.1039/c9ob00912d.
Friedel-Crafts benzylation of arenes with benzyl fluorides using 9-borabicyclo[3.3.l]nonane (9-BBN) as a mediator has been developed. This provides a simple and cheap route to the activation of C-F bonds to synthesize 1,1-diarylmethanes in good to excellent yields (up to 98%) under mild conditions. Functional group tolerance and the mechanism are considered.
开发了使用 9-硼杂双环[3.3.1]壬烷（9-BBN）作为介体的芳基与苄基氟的 Friedel-Crafts 苄基化反应。在温和条件下，该方法为 C-F 键的活化提供了一条简单、廉价的途径，以高产率（高达 98%）合成 1,1-二芳基甲烷。考虑了官能团耐受性和反应机理。
