多发性骨髓瘤的异基因骨髓移植

Allogeneic bone marrow transplantation in multiple myeloma.

作者信息

Gallamini A, Buffa F, Bacigalupo A, Van Lint M T, Peralvo J, Pittaluga P A, Occhini D, Marmont A M

出版信息

Acta Haematol. 1987;77(2):111-4. doi: 10.1159/000205969.

DOI:10.1159/000205969

Abstract

A 28-year-old woman with Bence-Jones multiple myeloma (MM) presented with several osteolytic lesions and a massive bone marrow infiltration with mature plasmocytes. After 6 cycles of chemotherapy with melphalan and prednisone, the patient, in apparent clinical remission, underwent allogeneic bone marrow transplantation (BMT) from her brother. The patient has been followed up for 23 months, showing complete remission by clinical and laboratory criteria. Other cases of MM treated with BMT and reported in the literature are reviewed and discussed.

摘要

一名患有本-周氏蛋白多发性骨髓瘤（MM）的28岁女性出现了多处溶骨性病变以及大量成熟浆细胞浸润骨髓。在用美法仑和泼尼松进行6个周期的化疗后，该患者表面上处于临床缓解期，接受了来自其兄弟的异基因骨髓移植（BMT）。对该患者进行了23个月的随访，根据临床和实验室标准显示完全缓解。本文对文献中报道的其他接受BMT治疗的MM病例进行了回顾和讨论。