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关于肠造口静脉曲张出血的病例系列:表现与处理。

Case Series Regarding Parastomal Variceal Bleeding: Presentation and Management.

机构信息

Department of Medicine, University of Alabama at Birmingham, Birmingham AL, USA.

Department of Medicine, University of Alabama at Birmingham, Birmingham AL, USA.

出版信息

Ann Hepatol. 2019 Jan-Feb;18(1):250-257. doi: 10.5604/01.3001.0012.7934.

DOI:10.5604/01.3001.0012.7934
PMID:31113601
Abstract

Parastomal variceal bleeding (PVB) is a serious complication occurring in up to 27% of patients with an ostomy and concurrent cirrhosis and portal hypertension. The management of PVB is difficult and there are no clear guidelines on this matter. Transjugular intrahepatic portosystemic shunt (TIPS), sclerotherapy, and /or coil embolization are all therapies that have been shown to successfully manage PVB. We present a case series with five different patients who had a PVB at our institution. The aim of this case series is to report our experience on the management of this infrequently reported but serious condition. We also conducted a systemic literature review focusing on the treatment modalities of 163 patients with parastomal variceal bleeds. In our series, patient 1 had embolization and sclerotherapy without control of bleed and expired on the day of intervention due to hemorrhagic shock. Patient 2 had TIPS in conjunction with embolization and sclerotherapy and had no instance of rebleed 441 days after therapy. Patient 3 did not undergo any intervention due to high risk for morbidity and mortality, the bleed self-resolved and there was no further rebleed, this same patient died of sepsis 73 days later. Patient 4 had embolization and sclerotherapy and had no instance of rebleed 290 days after therapy. Patient 5 had TIPS procedure and was discharged five days post procedure without rebleed, patient has since been lost to follow-up.

摘要

肠造口旁静脉曲张出血 (PVB) 是一种严重的并发症,在有造口和同时患有肝硬化和门静脉高压的患者中发生率高达 27%。PVB 的治疗较为困难,目前对此病并无明确的治疗指南。经颈静脉肝内门体分流术 (TIPS)、硬化疗法和/或线圈栓塞等疗法已被证明可成功治疗 PVB。我们报告了我院五例不同的 PVB 患者病例系列。本病例系列旨在报告我们在处理这种罕见但严重疾病方面的经验。我们还进行了一项系统的文献回顾,重点关注了 163 例肠造口旁静脉曲张出血患者的治疗方式。在我们的系列中,患者 1 接受了栓塞和硬化疗法治疗,但出血未得到控制,并在干预当天因失血性休克而死亡。患者 2 接受了 TIPS 联合栓塞和硬化疗法治疗,在治疗后 441 天没有再次出血。患者 3 由于高发病率和死亡率的风险而未接受任何干预,出血自行停止,此后也没有再次出血,该患者在 73 天后死于脓毒症。患者 4 接受了栓塞和硬化疗法治疗,在治疗后 290 天没有再次出血。患者 5 接受了 TIPS 手术,在术后五天出院,没有再次出血,此后患者失访。

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