Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, CHS 13-145, Los Angeles, CA, 90095, USA.
Curr Cardiol Rep. 2019 May 23;21(7):61. doi: 10.1007/s11886-019-1145-5.
This review describes numerous pathologic entities that cause structural abnormalities of the mitral valve. Different pathologic entities involve different components of the so-called mitral apparatus: atrial wall, annulus, leaflets, chordae, papillary muscles, and/or left ventricular free wall. These abnormalities can cause valvular stenosis, regurgitation, or both.
Currently, in addition to open-chest surgery to replace or repair the damaged mitral valve, there are less invasive percutaneous approaches to address mitral valve dysfunction. These include narrowing the orifice, clipping the leaflets, and inserting bioprostheses percutaneously. Understanding the structural abnormalities discussed in this review is essential for choosing the optimal therapeutic intervention for mitral valve disease.
本文描述了许多导致二尖瓣结构异常的病理实体。不同的病理实体涉及所谓的二尖瓣装置的不同组成部分:心房壁、瓣环、瓣叶、腱索、乳头肌和/或左心室游离壁。这些异常可导致瓣膜狭窄、反流或两者兼有。
目前,除了开胸手术置换或修复受损的二尖瓣外,还有一些微创的经皮方法可以解决二尖瓣功能障碍。这些方法包括缩小瓣口、夹闭瓣叶和经皮植入生物假体。理解本文讨论的结构异常对于选择二尖瓣疾病的最佳治疗干预至关重要。