Einhorn S, Ling P, Einhorn N, Strander H
J Clin Lab Immunol. 1987 May;23(1):35-8.
The influence of alpha-interferon (alpha-IFN) therapy on the capacity of blood lymphoid cells to produce alpha- and gamma-interferon (IFN) was studied in 21 patients with gynecological tumors, i.e., ovarian carcinoma (14 patients) or condylomata accuminata (7 patients). The mean capacity of the lymphoid cells to produce alpha-IFN in response to Sendai virus was increased, although not statistically significant, as compared to an age- and sex-matched control group, whereas the mean capacity of the patients' blood lymphoid cells to produce gamma-IFN in response to PHA or PWM was slightly decreased as compared to the control group. One day after the first injection of alpha-IFN there was a statistically significant decrease in the capacity of blood lymphoid cells to produce alpha-IFN and this decrease remained after 3 months of IFN therapy in most patients investigated. One week after initiation of alpha-IFN therapy there was a statistically significant decrease in the capacity of the cells to produce gamma-IFN in response to PHA or PWM and in most patients studied this decrease remained after 3 months of treatment. We conclude that the capacity of blood lymphoid cells to produce IFN is suppressed during exogenous alpha-IFN therapy.
在21例妇科肿瘤患者，即卵巢癌（14例）或尖锐湿疣（7例）中，研究了α-干扰素（α-IFN）治疗对血液淋巴细胞产生α-和γ-干扰素（IFN）能力的影响。与年龄和性别匹配的对照组相比，淋巴细胞对仙台病毒产生α-IFN的平均能力有所增加，尽管无统计学意义；而患者血液淋巴细胞对PHA或PWM产生γ-IFN的平均能力与对照组相比略有下降。首次注射α-IFN一天后，血液淋巴细胞产生α-IFN的能力有统计学意义的下降，并且在大多数接受研究的患者中，这种下降在IFN治疗3个月后仍然存在。α-IFN治疗开始一周后，细胞对PHA或PWM产生γ-IFN的能力有统计学意义的下降，并且在大多数研究患者中，这种下降在治疗3个月后仍然存在。我们得出结论，在外源性α-IFN治疗期间，血液淋巴细胞产生IFN的能力受到抑制。
