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一名接受过四次肾脏移植的患者感染百日咳博德特氏菌:呼吁在移植中心开展免疫计划。

Bordetella pertussis in a four-time kidney transplant recipient: A call for immunization programs at transplant centers.

作者信息

Hovel Elizabeth M, Pease Robert C, Scarano Andrew J, Chen Derrick J, Saddler Christopher M

机构信息

School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Department of Medicine, Division of Infectious Disease, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

出版信息

Transpl Infect Dis. 2019 Aug;21(4):e13120. doi: 10.1111/tid.13120. Epub 2019 Jun 14.

Abstract

Pertussis, or whooping cough, is a highly contagious respiratory illness caused most frequently by Bordetella pertussis. Clinical presentation ranges in severity, but life-threatening illness disproportionately affects children and immunocompromised individuals. Acellular vaccines for pertussis have been available for decades, and they are recommended throughout the lifespan. A patient who had received a kidney transplant presented with respiratory distress and dry cough as manifestations of co-infection with B pertussis and Bordetella parapertussis/bronchiseptica. The goal of this case report was to highlight the importance of immunization programs at transplant centers, which are in the unique position to care for patients both with end-stage organ disease and in the post-transplant setting.

摘要

百日咳,又称小儿咳嗽,是一种极具传染性的呼吸道疾病,最常见的病因是百日咳博德特氏菌。临床表现严重程度不一,但危及生命的疾病对儿童和免疫功能低下者的影响尤为严重。用于预防百日咳的无细胞疫苗已上市数十年,且建议在整个生命周期内接种。一名接受肾移植的患者出现呼吸窘迫和干咳,这是感染百日咳博德特氏菌和副百日咳博德特氏菌/支气管败血博德特氏菌的共同感染表现。本病例报告的目的是强调移植中心免疫规划的重要性,移植中心处于独特地位,能够照顾终末期器官疾病患者和移植后患者。

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