Barat A C, Harrie K, Jacob M, Diamantidis T G, McIntosh N L
JPEN J Parenter Enteral Nutr. 1987 Jul-Aug;11(4):384-8. doi: 10.1177/0148607187011004384.
The stability of total nutrient admixture (TNA) systems containing a soybean oil emulsion (Soyacal) has been reported with only one amino acid (AA) solution. This study was conducted to compare the physical stability of 10 TNA systems varied only by the AA solution used. All systems contained electrolytes, vitamins, trace elements, and heparin. The volume ratios of AA, dextrose 70% and lipid emulsion 20% were 1:1:1. Solutions were stored at 4 degrees C for 14 days and then held at ambient temperature for an additional 4 days. Each TNA was serially analyzed on days 0, 1, 3, 5, 7, 14, 15, 16, 17, and 18 for gross visual appearance, pH, osmolality, mean particle diameter, and particle size distribution. The AA solutions evaluated include: Travasol 8.5% and 10%; Aminosyn 8.5% and 10%, Aminosyn RF 5.2%; FreAmine III 8.5% and 10%; FreAmine HBC 6.9%; HepatAmine 8.0%; and NephrAmine 5.4%. The pH values of the Aminosyn solutions were lower than those of other products; however, the pH values of all TNA systems were greater than 5.7, which supported particle stability. The osmolality was not affected by the AA solutions. Based upon particle size distribution, 95% of all particles were less than 0.608 micron in diameter, with means ranging from 0.286 micron to 0.309 micron. The largest particle observed by light microscopy was 6.9 micron. These data indicate that TNA systems prepared with the 10 AA solutions and Soyacal 20% are physically stable.
据报道，含大豆油乳剂（Soyacal）的全营养混合液（TNA）系统仅与一种氨基酸（AA）溶液具有稳定性。本研究旨在比较10种仅因所用AA溶液不同而各异的TNA系统的物理稳定性。所有系统均含有电解质、维生素、微量元素和肝素。AA、70%葡萄糖和20%脂质乳剂的体积比为1:1:1。溶液在4℃下储存14天，然后在室温下再保存4天。在第0、1、3、5、7、14、15、16、17和18天对每种TNA进行连续分析，检测总体外观、pH值、渗透压、平均粒径和粒径分布。所评估的AA溶液包括：8.5%和10%的特拉伐索；8.5%和10%的复方氨基酸8.5%、5.2%的复方氨基酸（15）；8.5%和10%的凡命；6.9%的肝用氨基酸；8.0%的肝安；以及5.4%的肾必氨。复方氨基酸溶液的pH值低于其他产品；然而，所有TNA系统的pH值均大于5.7，这支持了颗粒的稳定性。渗透压不受AA溶液的影响。基于粒径分布，所有颗粒的95%直径小于0.608微米，平均值在0.286微米至0.309微米之间。光学显微镜观察到的最大颗粒为6.9微米。这些数据表明，用10种AA溶液和20%的Soyacal制备的TNA系统在物理上是稳定的。
