State Key Laboratory and Institute of Elemento-organic Chemistry , College of Chemistry, Nankai University , Tianjin 300071 , China.
Org Lett. 2019 Jun 7;21(11):4111-4115. doi: 10.1021/acs.orglett.9b01290. Epub 2019 May 24.
A protocol for highly enantioselective hydrogenation of racemic α-arylamino lactones with catalysis by site-specifically modified chiral spiro iridium complexes has been developed. With the optimized catalyst, racemic α-arylamino-γ-lactones and α-arylamino-δ-lactones could be hydrogenated to the corresponding chiral 2-amino diols with good to excellent enantioselectivities.
已开发出一种通过手性螺环铱配合物的位点特异性修饰进行催化的对映选择性高的外消旋α-芳基氨基内酰胺的氢化反应的方案。使用优化的催化剂，外消旋α-芳基氨基-γ-内酰胺和α-芳基氨基-δ-内酰胺可以被氢化得到相应的手性 2-氨基二醇，具有良好到优异的对映选择性。
