Ptácková B, Kucera F, Tacev T, Kabela M, Kopecný J, Spurný V, Zatocil P
Neoplasma. 1987;34(3):337-45.
During the period of January 1969 to December 1980, 649 patients have been treated by radical radiotherapy for Stage IIb, IIIb, and IVa carcinoma of the cervix uteri. This retrospective study was performed to assess therapeutical results in two groups of patients. Clinical staging and the methods of treatment were standard in both groups. Group I was treated by external irradiation of the pelvis minor with 60Co in combination with intracavitary radium administration. Group II patients were irradiated with a 42 MeV betatron according to the findings of lymphography, again in combination with radium brachytherapy. In Group I the 5-year survival rate was 59.2%, that in Group II was 66.7%. There was a statistically significant difference in the 5-year survival rate in Stage IIb patients of Group II (85.5%) against that in Group I (75.6%). The incidence of serious complications elicited by radiotherapy increased from 4.8% in Group I patients to 7.5% in Group II. Clinical stage, age at the time of diagnosis, findings of lymphography and tolerance to irradiation are prognostically important factors that influence the cure of the patients. On the basis of these findings, the possibilities of further therapeutic improvements are discussed.
1969年1月至1980年12月期间，649例子宫颈IIb期、IIIb期和IVa期癌患者接受了根治性放射治疗。进行这项回顾性研究以评估两组患者的治疗结果。两组患者的临床分期和治疗方法均为标准方法。第一组采用60Co对小骨盆进行外照射并结合腔内镭疗。第二组患者根据淋巴造影结果，采用42兆电子伏电子感应加速器进行照射，同样结合镭近距离治疗。第一组的5年生存率为59.2%，第二组为66.7%。第二组IIb期患者的5年生存率（85.5%）与第一组（75.6%）相比，差异具有统计学意义。放疗引起的严重并发症发生率从第一组患者的4.8%升至第二组的7.5%。临床分期、诊断时年龄、淋巴造影结果和对放疗的耐受性是影响患者治愈的重要预后因素。基于这些发现，讨论了进一步改善治疗的可能性。
