Goding G S, Richardson M A, Trachy R E
Otolaryngol Head Neck Surg. 1987 Jul;97(1):28-38. doi: 10.1177/019459988709700106.
The laryngeal chemoreflex (LCR) was investigated in 21 piglets (ages 6 to 80 days old) with the use of physiologic and histologic techniques. The central projection of the superior laryngeal nerve (SLN) was determined in 14 animals by use of horseradish peroxidase-wheat germ agglutinin. Ipsilateral labeling of the solitary tract nucleus was seen. The caudal extent of the labeling varied with age. Sensory labeling of the nucleus ambiguus was present bilaterally in three younger animals and unilaterally in older piglets. Bilateral labeling of the nucleus dorsomedialis was seen in all ages. Apneic and cardiovascular response to water stimulation of laryngeal mucosa and the laryngeal adductor reflex (LAR) were examined in 16 piglets. Blunting of the apneic and cardiovascular response was seen after sacrifice of a single SLN. Hypoxia did not significantly affect the LAR or apnea duration in animals with only one intact SLN. A contralateral LAR was found in younger animals. Relevance to the LCR is also discussed.
采用生理学和组织学技术对21头仔猪（6至80日龄）的喉化学反射（LCR）进行了研究。在14只动物中，通过使用辣根过氧化物酶-小麦胚凝集素确定了喉上神经（SLN）的中枢投射。观察到孤束核的同侧标记。标记的尾端范围随年龄而变化。在三只较年幼的动物中，疑核的感觉标记双侧存在，而在较年长的仔猪中单侧存在。在所有年龄段均观察到背内侧核的双侧标记。在16只仔猪中检查了对喉黏膜水刺激的呼吸暂停和心血管反应以及喉内收肌反射（LAR）。切断单根SLN后，呼吸暂停和心血管反应减弱。在仅有一根完整SLN的动物中，缺氧对LAR或呼吸暂停持续时间没有显著影响。在较年幼的动物中发现了对侧LAR。还讨论了其与LCR的相关性。
