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金属小梁骨重建系统改善股骨头坏死的临床疗效和生物力学修复优于游离腓骨移植:一项病例对照研究。

Metal trabecular bone reconstruction system better improves clinical efficacy and biomechanical repair of osteonecrosis of the femoral head than free vascularized fibular graft: A case-control study.

机构信息

Department of Osteonecrosis of the Femeral Head, Luoyang Orthopedics Hospital of Henan Province, Luoyang, P.R. China.

Department of Hip Injury, Luoyang Orthopedics Hospital of Henan Province, Luoyang, P.R. China.

出版信息

J Cell Physiol. 2019 Nov;234(11):20957-20968. doi: 10.1002/jcp.28700. Epub 2019 May 24.

Abstract

In this study, we aim to compare and analyze the biomechanical repair and clinical efficacy of osteonecrosis of the femoral head (ONFH) with the use of metal trabecular bone reconstruction system and free vascularized fibular graft. The study enrolled 66 adult patients from medical records of nontraumatic ARCO 2A-3B stage ONFH. A simple ONFH model without surgical treatment was established in 13 cases, 29 cases were treated with metal trabecular bone reconstruction system, and 24 cases were treated with free vascularized fibular graft. Computer-recognized and extracted femur outlines were imported, and three-dimensional reconstructions were performed. The stress concentration and stress peak value were analyzed, and the Harris score, visual analog scale pain score, and operation status of the above patients were compared. Finally, quality of life assessment was performed using SF-36 scale. Metal trabecular bone reconstruction system provided less operation time, blood loss, and the total length of postoperative hospital stay than free vascularized fibular graft. Metal trabecular bone reconstruction system promoted bone reconstruction, increased bone mineral density and Harris score. The total clinical effective rate of young patients (20-40 years) was higher than that of older patients (41-60 years). Metal trabecular bone reconstruction system provided higher physical component summary, mental component summary, and role/social component summary than free vascularized fibular graft. This study demonstrates that both metal trabecular bone reconstruction system and free vascularized fibular graft can prevent or delay the progression of ONFH, while metal trabecular bone reconstruction system is a better choice because of better short-term clinical efficacy.

摘要

在这项研究中,我们旨在比较和分析使用金属小梁骨重建系统和游离血管化腓骨移植治疗股骨头坏死(ONFH)的生物力学修复和临床疗效。该研究纳入了 66 例非创伤性 ARCO 2A-3B 期 ONFH 病历的成年患者。13 例建立单纯性 ONFH 模型,不进行手术治疗;29 例行金属小梁骨重建系统治疗;24 例行游离血管化腓骨移植治疗。导入计算机识别和提取的股骨轮廓,并进行三维重建。分析了应力集中和应力峰值,比较了上述患者的 Harris 评分、视觉模拟疼痛评分和手术情况。最后,使用 SF-36 量表进行生活质量评估。金属小梁骨重建系统的手术时间、出血量和术后住院总时间均少于游离血管化腓骨移植。金属小梁骨重建系统促进了骨重建,增加了骨矿物质密度和 Harris 评分。20-40 岁的年轻患者的总临床有效率高于 41-60 岁的患者。金属小梁骨重建系统的生理成分总分、心理成分总分和角色/社会成分总分均高于游离血管化腓骨移植。本研究表明,金属小梁骨重建系统和游离血管化腓骨移植均可预防或延缓 ONFH 的进展,而金属小梁骨重建系统具有更好的短期临床疗效,是更好的选择。

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