PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain; Department of Medicine, Division of Endocrinology, And Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Galeno Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain.
J Therm Biol. 2019 May;82:186-196. doi: 10.1016/j.jtherbio.2019.04.009. Epub 2019 Apr 20.
Brown adipose tissue (BAT) thermogenic activity is commonly assessed with a positron emission tomography with computed tomography scan (PET/CT). This technique has several limitations and alternative techniques are needed. Supraclavicular skin temperature measured with iButtons and infrared thermography (IRT) has been proposed as an indirect marker of BAT activity. We studied the concurrent validity of skin temperature measured with iButtons vs. IRT and the association of supraclavicular skin temperature measured with iButtons and IRT with BAT. We measured skin temperature upon a shivering threshold test with iButtons and IRT in 6 different regions in 12 participants (n = 2 men). On a separate day, we determined supraclavicular skin temperature with an iButton and IRT after 2 h of a personalized cooling protocol. Thereafter, we quantified BAT volume and activity by PET/CT. We observed that the absolute differences between the devices were statistically different from 0 (all P < 0.05) after the shivering threshold test. Moreover, we did not find any association between supraclavicular skin temperature measured with iButtons or IRT and BAT F-FDG activity (r = -0.213; P = 0.530 and r = -0.079; P = 0.817). However, we observed a negative association of supraclavicular skin temperature measured by IRT with BAT F-FDG volume (r = -0.764; P = 0.006), but not with supraclavicular skin temperature measured with iButtons (r = -0.546; P = 0.082). In light of these results, we concluded that the measurement of skin temperature obtained by iButtons and IRT are not comparable. Furthermore, it seems that supraclavicular skin temperature is not associated with BAT F-FDG activity, but it appears to be negatively associated with BAT F-FDG volume in the case of IRT.
棕色脂肪组织 (BAT) 的产热活性通常通过正电子发射断层扫描与计算机断层扫描 (PET/CT) 进行评估。该技术有几个局限性，需要替代技术。使用 iButton 测量的锁骨上皮肤温度和红外热成像 (IRT) 已被提议作为 BAT 活性的间接标志物。我们研究了 iButton 与 IRT 测量的皮肤温度之间的同时效度以及 iButton 和 IRT 测量的锁骨上皮肤温度与 BAT 之间的关联。我们在 12 名参与者的 6 个不同部位使用 iButton 和 IRT 测量了颤抖阈值测试时的皮肤温度（n=2 名男性）。在另一天，我们在个性化冷却方案 2 小时后使用 iButton 和 IRT 测量了锁骨上皮肤温度。之后，我们通过 PET/CT 定量了 BAT 体积和活性。我们观察到颤抖阈值测试后，设备之间的绝对差异具有统计学意义（所有 P < 0.05）。此外，我们没有发现 iButton 或 IRT 测量的锁骨上皮肤温度与 BAT F-FDG 活性之间存在任何关联（r= -0.213；P= 0.530 和 r= -0.079；P= 0.817）。然而，我们观察到 IRT 测量的锁骨上皮肤温度与 BAT F-FDG 体积呈负相关（r= -0.764；P= 0.006），但与 iButton 测量的锁骨上皮肤温度无关（r= -0.546；P= 0.082）。鉴于这些结果，我们得出结论，iButton 和 IRT 获得的皮肤温度测量值不可比。此外，似乎锁骨上皮肤温度与 BAT F-FDG 活性无关，但在 IRT 的情况下，它似乎与 BAT F-FDG 体积呈负相关。
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