Nazem Mohammad Reza, Asadi Mojgan, Jabbari Niloofar, Allameh Abdolamir
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Clin Biochem. 2019 Jul;69:15-20. doi: 10.1016/j.clinbiochem.2019.05.008. Epub 2019 May 23.
Despite the current guidelines for the management of type 2 diabetes mellitus (T2DM), patients still struggle with the hyperglycemia consequences. Imbalance in zinc homeostasis, in particular, renders diabetic patients more susceptible to the damages of oxidative stress. This study aimed to evaluate the effects of zinc supplementation on the superoxide dismutase gene expression and enzyme activity in overweight individuals with T2DM. Additionally, biochemical parameters, such as fasting blood glucose (FBG), insulin, glycated hemoglobin (HbA1c), homeostasis model of assessment-insulin resistance (HOMA-IR), serum levels of zinc and lipid profile, were assessed.
In this randomized, double-blind, placebo-controlled trial, 70 overweight (BMI > 25) T2DM patients were selected based on the inclusion criteria. They were divided into two groups for supplementation of daily 50 mg zinc gluconate or placebo for 8 weeks. Blood samples were collected from all the individuals in the zinc group and controls for analysis.
The results showed that, in comparison with the control group, zinc supplementation increased both gene expression and enzyme activity of SOD (p < 0.01) as well as the levels of insulin (p = 0.02) among the patients in the zinc group. Moreover, there was a meaningful reduction in the levels of FBG, HbA1c and HOMA-IR value (p < 0.001), triglycerides and total cholesterol (p < 0.05) after the zinc treatment.
Taken together, the current study suggests that daily supplementation with 50 mg zinc gluconate could be a useful approach for the management of overweight T2DM.
IRCT2015083102.
尽管目前有2型糖尿病（T2DM）管理指南，但患者仍在与高血糖后果作斗争。特别是锌稳态失衡使糖尿病患者更容易受到氧化应激的损害。本研究旨在评估补充锌对超重T2DM患者超氧化物歧化酶基因表达和酶活性的影响。此外，还评估了生化参数，如空腹血糖（FBG）、胰岛素、糖化血红蛋白（HbA1c）、稳态模型评估-胰岛素抵抗（HOMA-IR）、血清锌水平和血脂谱。
在这项随机、双盲、安慰剂对照试验中，根据纳入标准选择了70名超重（BMI>25）的T2DM患者。他们被分为两组，分别每日补充50mg葡萄糖酸锌或安慰剂，为期8周。从锌组和对照组的所有个体中采集血样进行分析。
结果显示，与对照组相比，补充锌可增加锌组患者的超氧化物歧化酶（SOD）基因表达和酶活性（p<0.01）以及胰岛素水平（p=0.02）。此外，锌治疗后，FBG、HbA1c和HOMA-IR值（p<0.001）、甘油三酯和总胆固醇水平（p<0.05）有显著降低。
综上所述，本研究表明，每日补充50mg葡萄糖酸锌可能是管理超重T2DM的一种有效方法。
IRCT2015083102。
