Department of Mechanical Engineering, University of British Columbia, 2054-6250, Applied Science Lane, Vancouver, BC, V6T 1Z4, Canada; School of Biomedical Engineering, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Baylis Medical Company, 2775, Matheson Blvd. East, Mississauga, ON, L4W 4P7, Canada.
Comput Biol Med. 2019 Jul;110:79-92. doi: 10.1016/j.compbiomed.2019.05.003. Epub 2019 May 23.
Patients with severe aortic stenosis could regain the proper hemodynamic performance and cardiovascular output by restoring the diseased aortic valve with an artificial heart valve replacement. However, given the uniqueness of each patient, the hemodynamic improvements after an aortic valve replacement could vary. The biomechanical and hemodynamical parameters can be influenced by some major factors including the patient's blood pressure and hematocrit. Therefore, the objective of this study is to analyze the hemodynamics and valve mechanics of a bileaflet mechanical heart valve and investigate the hemorheological characteristics under the change of hematocrit. The fully coupled fluid-structure interaction (FSI) approach was used to model the hemodynamics and valve dynamics. Particle image velocimetry (PIV) experiments were conducted with in vitro benchtop model using ViVitro Pulse Duplicator to verify and validate the FSI models. The current numerical analysis revealed the hematocrit influenced the shear stress distributions over a cardiac cycle. The structural stresses in the mechanical valve were also affected by the distributions of the shear stress in the blood flow. Parameter dependencies found in the current study indicate that the hematocrit is influential when conducting patient-specific modelling of prosthetic heart valves.
严重主动脉瓣狭窄的患者可以通过人工心脏瓣膜置换恢复患病的主动脉瓣的正常血液动力学性能和心血管输出。然而，由于每个患者的独特性，主动脉瓣置换后的血液动力学改善可能会有所不同。生物力学和血液动力学参数可能受到一些主要因素的影响，包括患者的血压和血细胞比容。因此，本研究的目的是分析双叶机械心脏瓣膜的血液动力学和瓣膜力学，并研究血细胞比容变化下的血液流变学特性。使用完全耦合流固耦合（FSI）方法对血液动力学和瓣膜动力学进行建模。使用 ViVitro Pulse Duplicator 在体外台式模型上进行粒子图像测速（PIV）实验，以验证和验证 FSI 模型。目前的数值分析表明，血细胞比容会影响心脏周期内的剪切应力分布。血流中的剪切应力分布也会影响机械瓣膜的结构应力。当前研究中的参数依赖性表明，在进行人工心脏瓣膜的患者特异性建模时，血细胞比容是有影响的。
Zotero 插件