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超疏水性对双叶机械心脏瓣膜流体动力学的影响。

Impact of superhydrophobicity on the fluid dynamics of a bileaflet mechanical heart valve.

机构信息

Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA.

出版信息

J Mech Behav Biomed Mater. 2020 Oct;110:103895. doi: 10.1016/j.jmbbm.2020.103895. Epub 2020 Jul 6.

DOI:10.1016/j.jmbbm.2020.103895
PMID:32957201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11046437/
Abstract

OBJECTIVE

The objective of this study is to evaluate the impact of superhydrophobic coating on the hemodynamics and turbulence characteristics of a bileaflet mechanical valve in the context of evaluating blood damage potential.

METHODS

Two 3D printed bileaflet mechanical valves were hemodynamically tested in a pulse duplicator under physiological pressure and flow conditions. The leaflets of one of the two valves were sprayed with a superhydrophobic coating. Particle Image Velocimetry was performed. Pressure gradients (PG), effective orifice areas (EOA), Reynolds shear stresses (RSS) and instantaneous viscous shear stresses (VSS) were calculated.

RESULTS

(a) Without SH coating, the PG was found to be 14.53 ± 0.7 mmHg and EOA 1.44 ± 0.06 cm. With coating, the PG obtained was 15.21 ± 1.7 mmHg and EOA 1.39 ± 0.07 cm; (b) during peak systole, the magnitude of RSS with SH coating (110Pa) exceeded that obtained without SH coating (40 Pa) with higher probabilities to develop higher RSS in the immediate wake of the leaflet; (c) The magnitudes range of instantaneous VSS obtained with SH coating were slightly larger than those obtained without SH coating (7.0 Pa versus 5.0 Pa).

CONCLUSION

With Reynolds Shear Stresses and instantaneous Viscous Shear Stresses being correlated with platelet damage, SH coating did not lead to their decrease. While SH coating is known to improve surface properties such as reduced platelet or clot adhesion, the relaxation of the slip condition does not necessarily improve overall hemodynamic performance for the bileaflet mechanical valve design.

摘要

目的

本研究旨在评估超疏水涂层对双叶机械瓣血流动力学和湍流特性的影响，以评估其血液损伤潜力。

方法

在生理压力和流量条件下，使用脉冲复制仪对两个 3D 打印的双叶机械瓣进行血流动力学测试。其中一个瓣叶喷涂了超疏水涂层。进行了粒子图像速度测量。计算了压力梯度（PG）、有效开口面积（EOA）、雷诺切应力（RSS）和瞬时粘性切应力（VSS）。

结果

（a）无 SH 涂层时，PG 为 14.53 ± 0.7mmHg，EOA 为 1.44 ± 0.06cm。有涂层时，PG 为 15.21 ± 1.7mmHg，EOA 为 1.39 ± 0.07cm；（b）在收缩期峰值时，具有 SH 涂层的 RSS 幅度（110Pa）超过了无 SH 涂层的 RSS 幅度（40Pa），在瓣叶的直接尾流中更有可能产生更高的 RSS；（c）具有 SH 涂层的瞬时 VSS 幅度范围略大于无 SH 涂层的幅度范围（7.0Pa 与 5.0Pa）。

结论

由于雷诺切应力和瞬时粘性切应力与血小板损伤相关，因此 SH 涂层并未导致其减少。虽然众所周知，SH 涂层可以改善表面性能，如减少血小板或血栓附着，但滑流条件的放松并不一定能改善双叶机械瓣设计的整体血流动力学性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c9/11046437/0979e0e0cf6f/nihms-1984671-f0014.jpg
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