腰椎间盘突出症患者椎间盘组织感染及不同抗生素敏感性
Infection in Disc Material and Different Antibiotic Susceptibility in Patients With Lumbar Disc Herniation.
作者信息
Salehpour Firooz, Aghazadeh Javad, Mirzaei Farhad, Ziaeii Ehsan, Alavi Seyed Ahmad Naseri
机构信息
Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Int J Spine Surg. 2019 Apr 30;13(2):146-152. doi: 10.14444/6019. eCollection 2019 Apr.
BACKGROUND
Low back pain is an important, worldwide clinical problem from which human populations are suffering. It has been suggested that is associated with low back pain. The objective of this clinical study is to evaluate the infection in the disc material and antibiotic susceptibility in patients with disc herniation.
METHODS
A total of 120 patients with disc herniation surgery were enrolled in the study. The samples were excited during discectomy and then cultured in both anaerobic and aerobic incubations. Minimum inhibitory concentration (MIC) was performed for determination of antibiotic susceptibility.
RESULTS
Of 120 samples, 60 (50%) samples were positive for microorganisms. Disc herniation was at the level of L4-L5 in 63 cases and L5-S1 in 57 cases.
CONCLUSIONS
According to the results and presence of in more than 35% of the cultured samples, the presence of in lumbar disc herniation is a suspected element leading to this condition. After analysis of the antibiotics, the lowest MIC value was identified for amoxicillin, ciprofloxacin, erythromycin, rifampicin, tetracycline, vancomycin; the moderate MIC value was for fusidic acid; and the highest MIC value was for gentamicin and trimethoprim.
背景
腰痛是一个重要的全球性临床问题，人类深受其害。有人认为[此处原文缺失相关内容]与腰痛有关。本临床研究的目的是评估椎间盘突出症患者椎间盘材料中的[此处原文缺失相关内容]感染情况及抗生素敏感性。
方法
本研究共纳入120例行椎间盘突出症手术的患者。在椎间盘切除术过程中采集样本，然后在厌氧和需氧培养条件下进行培养。采用最低抑菌浓度（MIC）测定抗生素敏感性。
结果
120份样本中，60份（50%）微生物检测呈阳性。63例椎间盘突出位于L4-L5水平，57例位于L5-S1水平。
结论
根据结果以及超过35%的培养样本中存在[此处原文缺失相关内容]，腰椎间盘突出症中[此处原文缺失相关内容]的存在是导致这种情况的一个可疑因素。对抗生素进行分析后，发现阿莫西林、环丙沙星、红霉素、利福平、四环素、万古霉素的MIC值最低；夫西地酸的MIC值中等；庆大霉素和甲氧苄啶的MIC值最高。
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