P波指标——深化我们对心房颤动相关心血管结局的理解
P Wave Indices-Advancing Our Understanding of Atrial Fibrillation-Related Cardiovascular Outcomes.
作者信息
Chen Lin Y, Soliman Elsayed Z
机构信息
Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, United States.
Department of Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, United States.
出版信息
Front Cardiovasc Med. 2019 May 3;6:53. doi: 10.3389/fcvm.2019.00053. eCollection 2019.
Atrial fibrillation (AF) is associated with an increased risk of ischemic stroke, heart failure, cognitive decline, dementia, myocardial infarction, sudden cardiac death (SCD), and all-cause death. Although these associations are firmly established, our understanding of the underlying mechanisms remains incomplete. Accumulating evidence suggests that left atrial (LA) abnormality or atrial cardiomyopathy may explain the relationship of AF to the aforementioned outcomes. P-wave indices (PWIs) reflect underlying atrial remodeling. In this mini review, we define representative PWIs, discuss state-of-the-art knowledge on the relationship between abnormal PWIs and AF-related cardiovascular outcomes (focusing on ischemic stroke and sudden cardiac death), and propose directions for future research. Our ultimate goal is to present a practical way forward to advance the emerging field of LA abnormality or atrial cardiomyopathy.
心房颤动（AF）与缺血性卒中、心力衰竭、认知功能下降、痴呆、心肌梗死、心源性猝死（SCD）及全因死亡风险增加相关。尽管这些关联已得到确凿证实，但我们对其潜在机制的理解仍不完整。越来越多的证据表明，左心房（LA）异常或心房心肌病可能解释AF与上述结局之间的关系。P波指数（PWIs）反映潜在的心房重构。在本综述中，我们定义了具有代表性的PWIs，讨论了关于异常PWIs与AF相关心血管结局（重点关注缺血性卒中和心源性猝死）之间关系的最新知识，并提出了未来研究方向。我们的最终目标是提出一条切实可行的前进道路，以推动LA异常或心房心肌病这一新兴领域的发展。
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