Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China.
Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
J Clin Lab Anal. 2019 Sep;33(7):e22925. doi: 10.1002/jcla.22925. Epub 2019 May 26.
miRNAs play important roles in a variety of diseases. Thus, the association between miRNA-196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility is still unknown.
We included 532 children with Kawasaki disease and 623 healthy children from South China, and their DNA was extracted for genotyping by TaqMan methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association.
No significant associations were observed between the miRNA-196a2 rs11614913 T>C polymorphisms and Kawasaki disease risk (TC vs TT: adjusted OR = 1.04, 95% CI = 0.79-1.37; CC vs TT: adjusted OR = 0.87, 95% CI = 0.63-1.21; dominant model: adjusted OR = 0.99, 95% CI = 0.76-1.27; and recessive model: adjusted OR = 0.85, 95% CI = 0.64-1.13). There was also no significant correlation found in stratified analyses.
This study suggests that miRNA-196a2 rs11614913 T>C may not be associated with Kawasaki disease susceptibility in a southern Chinese population. Larger, multicenter studies are needed to confirm our conclusions.
miRNAs 在多种疾病中发挥重要作用。因此，miRNA-196a2 rs11614913T>C 多态性与川崎病易感性之间的关联尚不清楚。
我们纳入了来自中国南方的 532 名川崎病患儿和 623 名健康对照儿童，并采用 TaqMan 法提取其 DNA 进行基因分型。计算比值比（OR）和 95%置信区间（CI）来评估关联强度。
miRNA-196a2 rs11614913T>C 多态性与川崎病风险之间无显著相关性（TC 与 TT：调整 OR=1.04，95%CI=0.79-1.37；CC 与 TT：调整 OR=0.87，95%CI=0.63-1.21；显性模型：调整 OR=0.99，95%CI=0.76-1.27；隐性模型：调整 OR=0.85，95%CI=0.64-1.13）。分层分析也未发现相关性。
本研究表明，miRNA-196a2 rs11614913T>C 多态性与中国南方人群川崎病易感性可能无关。需要更大规模、多中心的研究来证实我们的结论。
