该基因中的rs1625579 T>G多态性增加了中国南方人群患早发性川崎病的风险。
The rs1625579 T>G polymorphism in the gene confers a risk of early- onset Kawasaki disease in a southern Chinese population.
作者信息
Che Di, Li Jiawen, Fu Lanyan, Pi Lei, Rong Xing, Wang Yanfei, Xu Yufen, Huang Ping, Chu Maoping, Gu Xiaoqiong
机构信息
Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China,
Children's Heart Center, the Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China,
出版信息
Infect Drug Resist. 2018 Aug 3;11:1055-1060. doi: 10.2147/IDR.S174140. eCollection 2018.
BACKGROUND
Kawasaki disease (KD) mainly manifests as excessive inflammation and vascular endothelial cell injury. This disease generally occurs in children younger than 5 years of age and is more severe in children younger than 12 months. KD affects males and females at a ratio of 1.5:1. Polymorphisms of the rs1625579 locus in the gene are associated with schizophrenia susceptibility, and high glucose-induced upregulation of miR-137 in vascular endothelial cells promotes monocyte chemotaxis and inflammatory cytokine secretion in gestational diabetes mellitus. However, researchers have not reported whether rs1625579 is associated with KD susceptibility or onset. Therefore, we investigated the relationship between the rs1625579 T>G polymorphism and KD susceptibility.
METHODS
TaqMan real-time polymerase chain reaction was applied to determine the genotypes of 532 patients with KD (365 males and 167 females) and 623 control subjects (402 males and 221 females).
RESULTS
Comparison of all cases with all controls revealed that the rs1625579 T>G polymorphism was not associated with KD susceptibility. However, a subgroup analysis revealed that subjects with the rs1625579 TG/GG genotypes exhibited a significantly higher onset risk for KD before 12 months of age than carriers of the TT genotype (adjusted age and gender odds ratio=1.99, 95% CI=1.04-3.83; =0.039).
CONCLUSION
Our results indicate that the rs1625579 T>G polymorphism confers a risk of early-onset KD in southern Chinese children.
背景
川崎病（KD）主要表现为过度炎症反应和血管内皮细胞损伤。这种疾病通常发生在5岁以下儿童中，12个月以下儿童病情更为严重。KD在男性和女性中的发病比例为1.5:1。 基因中rs1625579位点的多态性与精神分裂症易感性相关，高糖诱导的血管内皮细胞中miR-137上调促进妊娠期糖尿病中单核细胞趋化和炎性细胞因子分泌。然而，研究人员尚未报道rs1625579是否与KD易感性或发病有关。因此，我们研究了rs1625579 T>G多态性与KD易感性之间的关系。
方法
应用TaqMan实时聚合酶链反应确定532例KD患者（365例男性和167例女性）和623例对照者（402例男性和221例女性）的基因型。
结果
所有病例与所有对照的比较显示，rs1625579 T>G多态性与KD易感性无关。然而，亚组分析显示，rs1625579 TG/GG基因型的受试者在12个月龄前患KD的发病风险显著高于TT基因型携带者（校正年龄和性别比值比=1.99，95%CI=1.04-3.83；P=0.039）。
结论
我们的结果表明，rs1625579 T>G多态性使中国南方儿童有早发性KD的风险。
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