Shalev O, Gilon D, Nubani N H
Acta Haematol. 1987;77(3):186-7. doi: 10.1159/000205989.
We report the occurrence of megaloblastic hematopoiesis with peripheral microcytosis in a beta-thalassemic heterozygote who developed profound anemia secondary to folate deficiency. The folate deficiency was precipitated by prolonged therapy with diphenylhydantoin. In thalassemic heterozygotes who develop anemia, the possibility of a megaloblastic pathogenesis should be pursued even when the RBC indices maintain their microcytic-hypochromic expression.
我们报告了一名β地中海贫血杂合子出现巨幼细胞性造血伴外周血小红细胞症，该患者因叶酸缺乏继发严重贫血。叶酸缺乏是由长期使用苯妥英治疗诱发的。在发生贫血的地中海贫血杂合子中，即使红细胞指数维持其小细胞低色素表现，也应探究巨幼细胞发病机制的可能性。
