Parys S, Eranki A, Khamhing S
G Chir. 2019 Mar-Apr;40(2):88-94.
To investigate the ability of White Cell Count (WCC), Neutrophil count & C-Reactive Protein (CRP) levels at admission to predict length of stay (LOS) in patients with uncomplicated diverticulitis.
This study was performed as a retrospective review of all patients admitted with CT proven uncomplicated diverticulitis over a one-year period. WCC, Neutrophils and CRP levels where recorded at admission. Uniform discharge criteria where used and length of stay measured. A correlation analysis was performed between the inflammatory markers and LOS.
A total of 84 admissions with uncomplicated diverticulitis was included in this study. Average LOS 3.06 (range 1-7 days). On Romaadmission average CRP was 55 (1-276), WCC 11.5 (4.5-35.6) and Neutrophils 8.37 (2.3-18.9). Peak inflammatory values were also measured with mean peak CRP 93.5 (3-325), WCC 11.6 (5.1-35.6) and neutrophils 8.47 (2.3-18.9). Inflammatory markers were correlated to LOS. Multivariate analysis and Fit Plots showed no correlation between any of the inflammatory markers and LOS. Using a modified Hinchey classification 8 patients were Hinchey 0, 60 Hinchey Ia and 16 Hinchey Ib. Hinchey classification was associated with longer LOS (Hinchey 0 mean LOS 2.63 days, Hinchey Ia 2.71 days, Hinchey Ib 4.4 days).
There was a high degree of variation in the inflammatory markers at admission, as well as the peak level of these inflammatory markers during the patients stay. The extent to which these markers were raised did not correlate with the patients' length of stay. As such, the use of inflammatory markers has limited prognostic value in patients with uncomplicated diverticulitis.
研究入院时白细胞计数（WCC）、中性粒细胞计数及C反应蛋白（CRP）水平预测单纯性憩室炎患者住院时间（LOS）的能力。
本研究对所有经CT证实为单纯性憩室炎且在一年期间入院的患者进行回顾性分析。记录入院时的WCC、中性粒细胞及CRP水平。采用统一的出院标准并测量住院时间。对炎症标志物与住院时间进行相关性分析。
本研究共纳入84例单纯性憩室炎患者。平均住院时间3.06天（范围1 - 7天）。入院时平均CRP为55（1 - 276），WCC为11.5（4.5 - 35.6），中性粒细胞为8.37（2.3 - 18.9）。还测量了炎症峰值，平均峰值CRP为93.5（3 - 325），WCC为11.6（5.1 - 35.6），中性粒细胞为8.47（2.3 - 18.9）。炎症标志物与住院时间相关。多因素分析和拟合图显示炎症标志物与住院时间之间无相关性。采用改良的欣奇分类法，8例患者为欣奇0级，60例为欣奇Ia级，16例为欣奇Ib级。欣奇分类与较长的住院时间相关（欣奇0级平均住院时间2.63天，欣奇Ia级2.71天，欣奇Ib级4.4天）。
入院时炎症标志物以及患者住院期间这些炎症标志物的峰值水平存在高度差异。这些标志物升高的程度与患者的住院时间无关。因此，炎症标志物在单纯性憩室炎患者中的预后价值有限。
