Wu Fan, Yang Hongyan, Liu Bin
Department of Gynaecology and Obstetrics, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Department of Neurology, Tongji Hospital Branch, Tongji University, Shanghai, China.
J Vasc Res. 2019;56(3):152-159. doi: 10.1159/000500358. Epub 2019 May 27.
Growing evidence has reported that a history of preeclampsia (PE) increases the risk of developing cardiovascular disease (CVD). Arterial stiffness plays a predictive role in CVD. Previous studies have demonstrated the close association between homocysteine (Hcy) level and arterial stiffness in community-based populations. This study was to assess whether Hcy level was independently associated with arterial stiffness in 168 women with a PE history who were analyzed at a 5-year follow-up. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse-wave analyzer and a value >1,400 cm/s was defined as high arterial stiffness. Biochemical parameters were recorded and an Hcy value >10 μmol/L was defined as having hyperhomocysteine (H-Hcy). Variables that were significantly associated with baPWV were tested for independence by multivariate logistic regression analysis. We found that body mass index (OR 1.017, 95% CI 1.008-1.029), systolic blood pressure (OR 1.048, 95% CI 1.019-1.072), total cholesterol (OR 1.059, 95% CI 1.007-1.086), and Hcy level (OR 1.021, 95% CI 1.010-1.037) were independent determinants of baPWV in women with previous PE. Our findings indicate that Hcy pathway might be involved in arterial stiffness in women with a PE history. Whether Hcy would be a promising biomarker for serial stratified CVD risk management in these women deserves further evaluation on a large scale.
越来越多的证据表明，子痫前期（PE）病史会增加患心血管疾病（CVD）的风险。动脉僵硬度在心血管疾病中起预测作用。先前的研究已经证明，在社区人群中，同型半胱氨酸（Hcy）水平与动脉僵硬度之间存在密切关联。本研究旨在评估在168名有子痫前期病史的女性中，经过5年随访分析，Hcy水平是否与动脉僵硬度独立相关。通过自动脉搏波分析仪测量肱踝脉搏波速度（baPWV），baPWV值>1400 cm/s被定义为高动脉僵硬度。记录生化参数，Hcy值>10 μmol/L被定义为高同型半胱氨酸血症（H-Hcy）。通过多因素逻辑回归分析测试与baPWV显著相关的变量的独立性。我们发现，体重指数（OR 1.017，95% CI 1.008-1.029）、收缩压（OR 1.048，95% CI 1.019-1.072）、总胆固醇（OR 1.059，95% CI 1.007-1.086）和Hcy水平（OR 1.021，95% CI 1.010-1.037）是既往有子痫前期的女性baPWV的独立决定因素。我们的研究结果表明，Hcy通路可能参与了有子痫前期病史女性的动脉僵硬度。Hcy是否会成为这些女性连续分层心血管疾病风险管理的有前景的生物标志物，值得进一步大规模评估。
