Chung In Won, Jeong Seong Hoon, Jung Hee Yeon, Youn Tak, Kim Se Hyun, Kim Yong Sik
Department of Psychiatry, Dongguk University International Hospital, Goyang, Republic of Korea.
Institute of Clinical Psychopharmacology, Dongguk University College of Medicine, Goyang, Republic of Korea.
Psychiatry Investig. 2019 May;16(5):403-406. doi: 10.30773/pi.2019.03.20. Epub 2019 May 23.
This study explored long-term changes in self-report auditory verbal hallucinations (AVHs) among patients with schizophrenia taking clozapine. Forty-four patients who were evaluated more than twice and were above the mild severity category on the Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ) were enrolled. The mean observation period was 492.5±350.1 days (median, 452 days). The mean total, physical, and emotional factor scores on the HPSVQ were significantly reduced from baseline to the final observations except for one item "interference with life," which was not significantly reduced. Regarding the time-dependent longitudinal changes modeled using linear mixed-effect regression, the total and physical factor scores showed significant changes during the first year, but the emotional factor score did not satisfy a more stringent level of significance. Female gender was negatively associated with the reduction in total and physical factor scores. The duration of treatment with clozapine also had a negative relationship with the reductions in all three scores.
本研究探讨了服用氯氮平的精神分裂症患者自我报告的幻听（AVH）的长期变化。招募了44名接受过两次以上评估且在汉密尔顿精神分裂症声音问卷（HPSVQ）上属于轻度以上严重程度类别的患者。平均观察期为492.5±350.1天（中位数为452天）。从基线到最终观察，HPSVQ上的平均总分、身体和情感因子得分均显著降低，但“对生活的干扰”这一项未显著降低。关于使用线性混合效应回归建模的时间依赖性纵向变化，总分和身体因子得分在第一年有显著变化，但情感因子得分未达到更严格的显著性水平。女性性别与总分和身体因子得分的降低呈负相关。氯氮平的治疗时长与所有三项得分的降低也呈负相关。
