Chen Xudong, Liang Shengxiang, Pu Weidan, Song Yinnan, Mwansisya Tumbwene E, Yang Qing, Liu Haihong, Liu Zhening, Shan Baoci, Xue Zhimin
Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 410011, People's Republic of China.
Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China.
BMC Psychiatry. 2015 Jul 7;15:152. doi: 10.1186/s12888-015-0546-2.
Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.
High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs ("auditory hallucination" AH group), and 31 never experienced AVHs ("no hallucination" NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.
Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.
Abnormalities of cortical thickness in the Heschl's gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.
幻听是精神分裂症中最引人关注的现象之一，然而，幻听背后的大脑异常仍不清楚。本研究探讨了首发精神分裂症患者皮层厚度与幻听之间的关联。
对49例首发精神分裂症（FES）患者和50例匹配良好的健康对照（HCs）进行了高分辨率磁共振成像。在FES患者中，18例有持续性幻听（“幻听”AH组），31例从未经历过幻听（“无幻觉”NH组）。通过幻听评定量表（AHRS）对幻听的严重程度进行评分。研究了三组之间的皮层厚度差异及其与幻听严重程度的关联。
与HCs和NH患者相比，AH患者右侧颞横回的皮层厚度较低。AH患者皮层厚度的减少程度与幻听严重程度相关。
颞横回皮层厚度异常可能是精神分裂症幻听的生理因素。
