Carini C, Brostoff J, Wraith D G
Ann Allergy. 1987 Aug;59(2):110-7.
We have studied patients with the diagnoses of asthma, eczema, and arthralgia by monitoring the formation of immune complexes containing IgE after antigen egress from the gut before and after challenge with food. Following challenge, immune complexes containing IgE, IgG, and antigen are detectable in the circulation. Their appearance correlates with the production of symptoms. The effect of sodium cromoglycate was to prevent the appearance of complexes. This was associated with absence of symptoms. It is suggested that a local IgE-mediated mechanism acts as a "trigger" for the entry of antigen and the formation of immune complexes by altering the permeability of the gut mucosa. The resulting delayed onset symptoms could be viewed as a form of serum sickness with few or many target organs affected.
我们通过监测在食物激发前后肠道内抗原排出后含IgE免疫复合物的形成，对诊断为哮喘、湿疹和关节痛的患者进行了研究。激发后，循环中可检测到含IgE、IgG和抗原的免疫复合物。它们的出现与症状的产生相关。色甘酸钠的作用是防止复合物的出现。这与无症状相关。提示局部IgE介导的机制通过改变肠黏膜通透性，作为抗原进入和免疫复合物形成的“触发因素”。由此产生的延迟出现的症状可被视为一种血清病形式，累及少数或多个靶器官。
