Turpin G
Arch Mal Coeur Vaiss. 1987 Apr;80 Spec No:37-42.
When only statistically comparable studies are taken into account, there are three primary prevention and eight secondary prevention studies. In 9 out these 11 studies the calculated decrease in the incidence of coronary disease are in favour of a beneficial effect of the lipid-lowering treatment. Some studies suggest that femoral atherosclerosis is receding and that coronary atherosclerosis is stable or progresses more slowly, but this always provided the plasma lipids are significantly and durably reduced. Subjects at high cardiovascular risk, therefore, must be treated, but one should now proceed even further, since the decrease of total cholesterol in the general population is paralleled by a decrease of coronary disease. This is in keeping with the results of extensive epidemiological surveys (notably the Framingham survey) which show that the lower the total cholesterol level the brighter the cardiovascular prognosis.
仅考虑具有统计学可比性的研究时，有三项一级预防研究和八项二级预防研究。在这11项研究中的9项中，计算得出的冠心病发病率下降表明降脂治疗具有有益效果。一些研究表明，股动脉粥样硬化正在消退，冠状动脉粥样硬化稳定或进展更缓慢，但这总是在血浆脂质显著且持久降低的情况下才会出现。因此，心血管风险高的受试者必须接受治疗，但现在应该更进一步，因为普通人群中总胆固醇的降低与冠心病的减少是平行的。这与广泛的流行病学调查结果（尤其是弗明汉姆调查）一致，该调查表明总胆固醇水平越低，心血管预后越好。
