Yang Guo-Hui, Zhao Qun, Zhang Zhi-Pei, Zheng Han-Liang, Chen Li, Li Xin
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
J Org Chem. 2019 Jun 21;84(12):7883-7893. doi: 10.1021/acs.joc.9b00749. Epub 2019 Jun 7.
A BINOL-based chiral phosphoric acid was employed as an efficient catalyst in enantioselective cycloaddition of ortho-hydroxyphenyl-substituted para-quinone methides and enamides, which gave rise to acetamido-substituted tetrahydroxanthenes with three adjacent stereogenic centers in high yields (up to 99%) and excellent stereoselectivities (up to >99:1 diastereomeric ratio and up to 98% ee).
一种基于联萘酚的手性磷酸被用作邻羟基苯基取代对醌甲基化物与烯酰胺对映选择性环加成反应的高效催化剂，该反应以高产率（高达99%）和优异的立体选择性（高达>99:1的非对映体比例和高达98%的对映体过量）生成具有三个相邻手性中心的乙酰氨基取代四氢呫吨。
