Nugteren D H, Kivits G A
Biochim Biophys Acta. 1987 Sep 4;921(1):135-41. doi: 10.1016/0005-2760(87)90179-2.
Two different lipoxygenases have been identified in human and rat epidermis. One lipoxygenase has a (n-9)-specificity, converts arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), and has been described by several investigators. Linoleic acid is not a substrate for this enzyme. The other lipoxygenase, with (n-6)-specificity, converts arachidonic acid into 15-HETE and linoleic acid into 13-hydroxyoctadecadienoic acid (13-HOD). Especially the latter lipoxygenase is thought to be involved in the regulation of the differentiation of the skin cells into a proper water-barrier layer. Linoleate is supposed to be the physiological substrate; this fatty acid is especially present in characteristic sphingolipids with unique structures.
在人和大鼠的表皮中已鉴定出两种不同的脂氧合酶。一种脂氧合酶具有（n-9）特异性，可将花生四烯酸转化为12-羟基二十碳四烯酸（12-HETE），已有多位研究者对其进行过描述。亚油酸不是这种酶的底物。另一种脂氧合酶具有（n-6）特异性，可将花生四烯酸转化为15-HETE，并将亚油酸转化为13-羟基十八碳二烯酸（13-HOD）。尤其后一种脂氧合酶被认为参与了皮肤细胞分化为合适的水屏障层的调节过程。亚油酸酯被认为是生理底物；这种脂肪酸尤其存在于具有独特结构的特征性鞘脂中。
