Mikolajczak Renata, van der Meulen Nicholas P, Lapi Suzanne E
Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland.
Laboratory of Radiochemistry, Paul Scherrer Institute, Villigen, Switzerland.
J Labelled Comp Radiopharm. 2019 Aug;62(10):615-634. doi: 10.1002/jlcr.3770. Epub 2019 Jul 23.
The aim of this review is to make the reader familiar with currently available radiometals, their production modes, capacities, and quality concerns related to their medical use, as well as new emerging radiometals and irradiation technologies from the perspective of their diagnostic and theranostic applications. Production methods of Lu serve as an example of various issues related to the production yield, specific activity, radionuclidic and chemical purity, and production economy. Other radiometals that are currently used or explored for potential medical applications, with particular focus on their theranostic value, are discussed. Using radiometals for diagnostic imaging and therapy is on the rise. The high demand for radiometals for medical use prompts investigations towards using alternative irradiation reactions, while using existing nuclear reactors and accelerator facilities. This review discusses these production capacities and what is necessary to cover the growing demand for theranostic nuclides.
本综述的目的是让读者熟悉目前可用的放射性金属、它们的生产方式、产量、与医学用途相关的质量问题，以及从诊断和治疗诊断应用的角度来看新兴的放射性金属和辐照技术。以镥的生产方法为例，说明与产量、比活度、放射性核素和化学纯度以及生产经济性相关的各种问题。讨论了目前正在使用或探索其潜在医学应用的其他放射性金属，特别关注它们的治疗诊断价值。使用放射性金属进行诊断成像和治疗的情况正在增加。对医用放射性金属的高需求促使人们在利用现有核反应堆和加速器设施的同时，研究使用替代辐照反应。本综述讨论了这些生产能力以及满足对治疗诊断核素不断增长的需求所需的条件。
