Komada H, Nakabayashi H, Idota M, Hara M, Takahashi T, Takanari H, Izutsu K
Cell Struct Funct. 1987 Jun;12(3):281-5. doi: 10.1247/csf.12.281.
Low concentrations of cytochalasin B enhanced the T cell mitogenesis induced by concanavalin A (Con A) and interleukin 2 (IL-2). Mitogenesis was augmented by cytochalasin B given in the Con A-dependent early phase, or through T cell mitogenesis. Cytochalasin B did not enhance T cell mitogenesis when given only in the IL-2-dependent late phase. Use of the monoclonal antibody that directs the IL-2 receptor showed that cytochalasin B increased the expression of the IL-2 receptor induced by Con A. We concluded that cytochalasin b acts on an early phase of T cell mitogenesis and augments the expression of IL-2 receptor which enables certain nonresponsive T cells to respond to IL-2.
低浓度的细胞松弛素B增强了伴刀豆球蛋白A（Con A）和白细胞介素2（IL-2）诱导的T细胞有丝分裂。在Con A依赖的早期阶段给予细胞松弛素B，或通过T细胞有丝分裂，有丝分裂会增强。仅在IL-2依赖的晚期给予细胞松弛素B时，它不会增强T细胞有丝分裂。使用针对IL-2受体的单克隆抗体表明，细胞松弛素B增加了Con A诱导的IL-2受体的表达。我们得出结论，细胞松弛素B作用于T细胞有丝分裂的早期阶段，并增强IL-2受体的表达，从而使某些无反应性的T细胞能够对IL-2作出反应。
