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可扩张内假体的结果:单中心回顾性研究。

Outcome of expandable endoprosthesis: A single centre retrospective review.

作者信息

Ajit Singh Vivek, Earnest Kunasingh Dinesh, Haseeb Amber, Yasin Nor Faissal

机构信息

Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

J Orthop Surg (Hong Kong). 2019 May-Aug;27(2):2309499019850313. doi: 10.1177/2309499019850313.

Abstract

PURPOSE

Expandable endoprosthesis allows limb salvage in children with an option to leading a better life. However, the revision rate and implant-related complications impose as a limitation in the skeletal immature. This study investigates the functional outcomes and complications related to expandable endoprosthesis in our centre.

MATERIALS AND METHODS

Twenty surviving patients with expandable endoprosthesis from 2006 till 2015 were scored using Musculoskeletal Tumour Society (MSTS) outcomes instrument and reviewed retrospectively for range of motion of respected joints, limb length discrepancy, number of surgeries performed, complications and oncological outcomes. Patients with less than 2 years of follow-up were excluded from this study.

RESULTS

Forty-five percentage patients reached skeletal maturity with initial growing endoprosthesis and 25% of patients were revised to adult modular prosthesis. One hundred fifty-seven surgeries were performed over the 9-year period. The average MSTS score was 90.83%. The mortality rate was 10% within 5 years due to advanced disease. Infection and implant failure rate was 15% each. The event-free survival was 50% and overall survival rate was 90%.

CONCLUSION

There is no single best option for reconstruction in skeletally immature. This study demonstrates a favourable functional and survival outcome of paediatric patients with expandable endoprosthesis. The excellent MSTS functional scores reflect that patients were satisfied and adjusted well to activities of daily living following surgery despite the complications.

摘要

目的

可扩张型内置假体可使儿童肢体得以保全,从而有机会过上更好的生活。然而,翻修率和与植入物相关的并发症限制了其在骨骼未成熟患者中的应用。本研究调查了我院使用可扩张型内置假体的功能结果及相关并发症。

材料与方法

对2006年至2015年期间20例使用可扩张型内置假体且存活的患者,采用肌肉骨骼肿瘤学会(MSTS)结果评估工具进行评分,并回顾性分析相关关节的活动范围、肢体长度差异、手术次数、并发症及肿瘤学结果。随访时间不足2年的患者被排除在本研究之外。

结果

45%的患者使用初始生长型内置假体达到骨骼成熟,25%的患者翻修为成人模块化假体。9年期间共进行了157次手术。MSTS平均评分为90.83%。由于疾病进展,5年内死亡率为10%。感染率和植入物失败率均为15%。无事件生存率为50%,总生存率为90%。

结论

对于骨骼未成熟患者的重建,没有单一的最佳选择。本研究表明,可扩张型内置假体在儿科患者中具有良好的功能和生存结果。尽管存在并发症,但MSTS出色的功能评分反映出患者对手术效果满意,且能很好地适应术后日常生活活动。

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