Komp D M, Vietti T J, Berry D H, Starling K A, Haggard M E, George S L
Med Pediatr Oncol. 1977;3(3):267-73. doi: 10.1002/mpo.2950030308.
Twenty-five children with generalized histiocytosis X were treated with a combination of cyclophosphamide, vinblastine, and prednisone: 8 patients experienced complete response, 8 partial response, 2 imporvement, and 7 no response. Response rates for children over 1 year of age were higher than those reported for single agents. Twelve children are now off therapy with no evidence of disease for 10--50 months. Very poor response rates and high toxicity were seen in children less than 1 year of age. The two infants who eventually achieved CR did so by other therapies. Further trials in combination chemotherapy must weight possible long-term effects of such therapy against the prospect of more rapid disease control.
25名全身性组织细胞增多症X患儿接受了环磷酰胺、长春碱和泼尼松联合治疗：8例完全缓解，8例部分缓解，2例病情改善，7例无反应。1岁以上儿童的缓解率高于单药治疗的报道。12名儿童现已停止治疗，10至50个月内无疾病证据。1岁以下儿童的缓解率非常低且毒性高。最终实现完全缓解的两名婴儿是通过其他疗法做到的。联合化疗的进一步试验必须权衡这种疗法可能的长期影响与更快控制疾病的前景。
