Wroe S J, Rimmer E, Kongola G, John R, Henley R, Richens A
Horm Metab Res. 1987 Jun;19(6):278-9. doi: 10.1055/s-2007-1011798.
Patients with epilepsy were found to have an increased 20 minute prolactin response to intravenous TRH stimulation when receiving the GABA-T inhibiting drug vigabatrin. Enhanced GABA activity may either reduce basal prolactin levels whilst allowing a normal pituitary response to TRH stimulation, or may overcome the inhibitory effects of dopamine on pituitary prolactin release.
研究发现，癫痫患者在服用γ-氨基丁酸转氨酶（GABA-T）抑制药物vigabatrin时，静脉注射促甲状腺激素释放激素（TRH）刺激后20分钟的催乳素反应增强。增强的GABA活性可能会降低基础催乳素水平，同时使垂体对TRH刺激产生正常反应，或者可能会克服多巴胺对垂体催乳素释放的抑制作用。
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