Gambacciani M, Melis G B, Paoletti A M, Cagnacci A, Mais V, Petacchi F D, Fioretti P
J Clin Endocrinol Metab. 1987 Sep;65(3):465-8. doi: 10.1210/jcem-65-3-465.
Pulsatile LH release was studied in 28 healthy postmenopausal women by obtaining blood samples every 5 min for 4 h either basally or after 30 days of bromocriptine (BCT; 3.75 mg/day; n = 14) or placebo (n = 14) administration. Basally, mean plasma LH levels were 46.3 +/- 3.5 (+/- SE) and 53.4 +/- 4.6 mIU/mL in the BCT and placebo groups, respectively. Mean LH pulse frequencies were 4.2 +/- 0.3 and 4.0 +/- 0.4 pulses/4 h, mean pulse amplitudes were 19.2 +/- 1.9 and 20.1 +/- 1.5 mIU/mL, and mean interpulse intervals were 54.3 +/- 3.1 and 54.6 +/- 3.2 min in the two groups, respectively. BCT administration induced no significant changes in mean plasma LH levels, but it significantly (P less than 0.01) decreased LH pulse frequency (1.7 +/- 0.3 pulses/4 h) and amplitude (12.7 +/- 0.8 mIU/mL) and significantly (P less than 0.01) increased mean interpulse interval (126.1 +/- 17.5 min). Placebo administration did not induce any significant changes in pulsatile LH release. These results demonstrate that in postmenopausal women LH secretion is circhoral, and BCT administration can blunt LH pulsatility, suggesting dopaminergic regulation of the GnRH-LH pulse generator.
对28名健康绝经后女性进行了促黄体生成素（LH）脉冲式释放的研究。在基础状态下，或在给予溴隐亭（BCT；3.75毫克/天；n = 14）或安慰剂（n = 14）30天后，每5分钟采集一次血样，共采集4小时。基础状态下，BCT组和安慰剂组的平均血浆LH水平分别为46.3±3.5（±标准误）和53.4±4.6毫国际单位/毫升。两组的平均LH脉冲频率分别为4.2±0.3和4.0±0.4次脉冲/4小时，平均脉冲幅度分别为19.2±1.9和20.1±1.5毫国际单位/毫升，平均脉冲间期分别为54.3±3.1和54.6±3.2分钟。给予BCT后，平均血浆LH水平无显著变化，但LH脉冲频率（1.7±0.3次脉冲/4小时）和幅度（12.7±0.8毫国际单位/毫升）显著降低（P<0.01），平均脉冲间期显著延长（126.1±17.5分钟）（P<0.01）。给予安慰剂后，LH脉冲式释放无任何显著变化。这些结果表明，绝经后女性的LH分泌呈昼夜节律性，给予BCT可减弱LH的脉冲性，提示多巴胺能对促性腺激素释放激素 - LH脉冲发生器有调节作用。
