基于甾醇的治疗对携带不同基因儿童血浆甘油三酯浓度的调节作用。

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

作者信息

San Mauro Martín Ismael, Sanz Rojo Sara, Garicano Vilar Elena, Collado Yurrita Luis, Blumenfeld Olivares Javier Andrés

机构信息

Research Centers in Nutrition and Health, Madrid, Spain.

Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain.

出版信息

Ann Pediatr Cardiol. 2019 May-Aug;12(2):83-89. doi: 10.4103/apc.APC_86_18.

DOI:10.4103/apc.APC_86_18

PMID:31143031

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6521671/

Abstract

BACKGROUND

Dyslipidemias have increased during the last decades in children.

AIM

The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols.

DESIGN

A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women).

MATERIALS AND METHODS

Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of kimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed.

RESULTS

Apolipoprotein A5 Ser19Trp ( = 0.002), peroxisome proliferator-activated receptor-alpha L162V ( = 0.003), APOE APOE2/3/4 ( = 0.012), and APOE APOE2,3,4 ( = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences.

CONCLUSIONS

Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.

摘要

背景

在过去几十年中，儿童血脂异常情况有所增加。

目的

本研究的目的是分析不同基因多态性对接受植物甾醇饮食治疗的儿童血浆甘油三酯水平的影响。

设计

对26名儿童（16名女性）进行了一项随机、双盲、交叉、对照临床试验。

材料与方法

在3周内每天摄入含有2.24克甾醇的市售牛奶，在为期3周的安慰剂阶段摄入等量不含甾醇的脱脂牛奶。两个阶段之间间隔2周的洗脱期。在每个阶段开始和结束时进行采血。

结果

载脂蛋白A5 Ser19Trp（P = 0.002）、过氧化物酶体增殖物激活受体α L162V（P = 0.003）、载脂蛋白E APOE2/3/4（P = 0.012）和载脂蛋白E APOE2,3,4（P = 0.025）在血浆甘油三酯水平的单倍型之间显示出统计学上的显著差异。其他基因未显示出统计学上的显著差异。