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[低脂、富含植物甾醇的发酵乳对降低儿童高甘油三酯血症的作用:一项双盲、随机、安慰剂对照试验]

[LOW-FAT, FERMENTED MILK ENRICHED WITH PLANT STEROLS, A STRATEGY TO REDUCE HYPERTRIGLYCERIDEMA IN CHILDREN, A DOUBLE-BLIND, RANDOMIZED PLACEBO-COTROLLED TRIAL].

作者信息

Blumenfeld Olivares Javier Andrés, San Mauro Martín Ismael, Calle Maria Elisa, Bischofberger Valdés Cornelia, Perez Arruche Eva, Arce Delgado Esperanza, Ciudad María Jose, Hernández Cabría Marta, Collado Yurita Luis

机构信息

Hospital Universitario El Escorial, San Lorenzo de El Escorial..

Facultad de Medicina, Universidad Complutense de Madrid..

出版信息

Nutr Hosp. 2015 Sep 1;32(3):1056-60. doi: 10.3305/nh.2015.32.3.9319.

Abstract

INTRODUCTION

in the last few years, as the rate of childhood obesity has been rising, there has been a parallel increase in the incidence of dislipemia in the pediatric population, in which blood triglycerids might play an important role. Plant sterols have been shown to be useful in the tratment of hypercholesterolemia, but not of hypertrygliceridemia. Our study focusses on determining the efficacy of phytosterol-supplemented milk for the treatment of hypertriglyceridemia in children. Study Population and Method: we designed a double- blind, randomized, controlled clinical trial on 67 pediatric patients. The treatment group received low-fat, phytosterol-supplemented milk and the control group received low-fat conventional milk.

RESULTS

we observed differences in triglyceridemia between the phytosterol-supplemented group and the non-supplemented group. The effect attributable to the intake of milk supplemented with plant sterols was a reduction of triglyceridemia of 5.88 mg/dl compared with the control group.

CONCLUSION

we conclude that phytosterol-supplemented milk (2.24 gr of plant sterols daily) might be an adequate tool in the management of hypertriglyceridemia in pediatric patients.

摘要

引言

在过去几年中,随着儿童肥胖率的上升,儿科人群中血脂异常的发病率也相应增加,其中血液甘油三酯可能起重要作用。植物甾醇已被证明对治疗高胆固醇血症有效,但对高甘油三酯血症无效。我们的研究重点是确定补充植物甾醇的牛奶对治疗儿童高甘油三酯血症的疗效。研究人群和方法:我们对67名儿科患者设计了一项双盲、随机、对照临床试验。治疗组接受低脂、补充植物甾醇的牛奶,对照组接受低脂常规牛奶。

结果

我们观察到补充植物甾醇组和未补充组之间甘油三酯血症存在差异。与对照组相比,摄入补充植物甾醇的牛奶导致甘油三酯血症降低了5.88mg/dl。

结论

我们得出结论,补充植物甾醇的牛奶(每日2.24克植物甾醇)可能是管理儿科患者高甘油三酯血症的合适工具。

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