Hansen B L, Rohr N, Svendsen V, Birkeland S A
Nephrol Dial Transplant. 1987;2(3):189-90.
The courses of 34 graft failures leading to graft nephrectomy in 19 patients were examined retrospectively. Cyclosporin (CsA) was the sole immunosuppressive in 70% of the cases, and azathioprine-prednisolone in 30%. Having diagnosed graft failure, the immunosuppressive treatment was continued for about 2-3 months and then tapered slowly. No deaths related to graft failure were recorded. In three cases a delay in graft nephrectomy caused complications such as sepsis and coagulopathy. We conclude that continuing immunosuppression a few months after having diagnosed graft failure may postpone or avoid graft nephrectomy while steroid withdrawal symptoms do not complicate the course at the time of graft failure.
对19例患者中导致移植肾切除的34次移植失败过程进行了回顾性研究。70%的病例中，环孢素（CsA）是唯一的免疫抑制剂，30%的病例中使用硫唑嘌呤-泼尼松龙。诊断移植失败后，免疫抑制治疗持续约2-3个月，然后缓慢减量。未记录到与移植失败相关的死亡病例。3例患者因移植肾切除延迟出现了败血症和凝血病等并发症。我们得出结论，在诊断移植失败后继续免疫抑制几个月，可能会推迟或避免移植肾切除，而在移植失败时撤停类固醇药物的症状不会使病程复杂化。
