School of Chemistry and Material Engineering, Changzhou Vocational Institute of Engineering, Changzhou, 213164, China.
School of Petrochemical and Engineering, Changzhou University, Changzhou, 213164, China.
Anal Chim Acta. 2019 Sep 23;1072:54-60. doi: 10.1016/j.aca.2019.04.039. Epub 2019 Apr 23.
In this work, we reported a novel electrochemical sensor for enantiorecognition of electrochemically inactive aspartic acid (Asp) enantiomers. By combining sol-gel processing with molecular imprinting technology, an enantioselective interface of molecularly imprinted sol-gel (MIS) films with imprinted cavities was prepared on the surface of a glassy carbon electrode (GCE). In order to obtain the electrochemical responses of electrochemically inactive Asp, the ternary derivative of -aspartic, (-aspartic acid)Cu(N-carbobenzoxy--aspartic acid), was used as the template for fabrication of MIS. The stripping currents of target molecules could be detected by square-wave stripping voltammetry due to the reduction of cupric ion on the modified electrode. The resulted sensor showed good adsorbability to -Asp derivative, and the recognition efficiency was obtained as 2.1. Meanwhile, the -Asp was quantitatively determined by the MIS sensor. As a result, the proposed electrochemical sensor could be regarded as a potential platform for enantiorecognition of electrochemically inactive chiral compounds.
在这项工作中，我们报道了一种用于对电非活性天冬氨酸（Asp）对映异构体进行对映体识别的新型电化学传感器。通过将溶胶-凝胶处理与分子印迹技术相结合，在玻碳电极（GCE）表面制备了具有印迹空穴的分子印迹溶胶-凝胶（MIS）膜的手性界面。为了获得电非活性 Asp 的电化学响应，-天冬氨酸（-aspartic acid）Cu（N-碳苯氧羰基--天冬氨酸）的三元衍生物被用作制造 MIS 的模板。由于修饰电极上铜离子的还原，可以通过方波溶出伏安法检测目标分子的溶出电流。所得传感器对 -Asp 衍生物具有良好的吸附能力，识别效率为 2.1。同时，通过 MIS 传感器对 -Asp 进行定量测定。因此，所提出的电化学传感器可以被视为电非活性手性化合物对映体识别的潜在平台。
