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[一例口服优福定、丝裂霉素C和香菇多糖后癌性腹膜炎得到改善的胃癌病例]

[A case of gastric cancer with peritonitis carcinomatosa which improved upon oral administration of UFT, mitomycin C and lentinan].

作者信息

Ishibashi H, Hirakawa K, Nakajima H, Ioka J, Shirono K, Tanabe S, Ochiai K, Tomita K, Kitagawa Y

出版信息

Gan To Kagaku Ryoho. 1987 Sep;14(9):2787-91.

PMID:3115187
Abstract

A 29-year-old male visited our hospital because of lower abdominal pain. Acute appendicitis was suspected, and surgery was performed. However, no abnormality was found in the vermiform appendix. Instead, atrophy of the greater omentum, numerous nodes of varying sizes, and a small amount of ascites were observed. On the basis of histological examination, a diagnosis of metastatic glandular cancer was made. Gastric fluoroscopy performed 2 months earlier in another hospital had revealed irregularity of the stomach wall and a large concave area on the side of the greater curvature. Photogastroscopy and CT demonstrated progressive Borrmann type III cancer at the corresponding site and metastasis to regional lymph nodes. Biopsy findings were similar to the histological findings. After 1 week, treatment with UFT (400 mg/day), MMC (10 mg/month) and LNT (1 mg/week) was initiated. After about 3 months, i.e., following administration of 40 g UFT, 30 mg MMC and 8 mg LNT, gastric fluoroscopy and photogastroscopy revealed complete disappearance of the tumor. No abnormality was found by laboratory studies. The patient has since returned to a normal life.

摘要

一名29岁男性因下腹部疼痛前来我院就诊。怀疑为急性阑尾炎,遂进行了手术。然而,阑尾未发现异常。相反,观察到大网膜萎缩、大小不一的多个结节以及少量腹水。根据组织学检查,诊断为转移性腺癌。两个月前在另一家医院进行的胃透视显示胃壁不规则,大弯侧有一大片凹陷区。胃摄影和CT显示相应部位为进展期Borrmann III型癌并伴有区域淋巴结转移。活检结果与组织学检查结果相似。1周后,开始使用优福定(400毫克/天)、丝裂霉素(10毫克/月)和香菇多糖(1毫克/周)进行治疗。大约3个月后,即服用40克优福定、30毫克丝裂霉素和8毫克香菇多糖后,胃透视和胃摄影显示肿瘤完全消失。实验室检查未发现异常。此后,患者已恢复正常生活。

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