Department of Health and Nutrition, University of Niigata Prefecture Faculty of Human Life Studies, 471 Ebigase, Higashi-ku, Niigata, 950-8680, Japan.
Department of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, 1-757 Asahimachi-dori, Chuoh-ku, Niigata, 951-8510, Japan.
Eur J Nutr. 2020 Jun;59(4):1585-1594. doi: 10.1007/s00394-019-02014-4. Epub 2019 May 31.
Although vitamin B6 has been suspected to prevent the progression of diabetic retinopathy, evidence of this in patients with type 2 diabetes based on longitudinal studies is sparse. This study investigated the relationship between vitamin B6 intake and the incidence of diabetic retinopathy in Japanese patients with type 2 diabetes.
The study was part of an examination of a nationwide cohort of patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 48 mmol/mol. After excluding nonresponders to a dietary survey using the Food Frequency Questionnaire based on food groups, 978 patients were analyzed. Primary outcome was the 8-year risk of a diabetic retinopathy event, and Cox regression analyses estimated hazard ratios (HRs) for retinopathy according to vitamin B6 intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders.
Mean vitamin B6 intake in quartiles ranged from 1.1 to 1.6 mg/day, and half of the participants had vitamin B6 intake below the recommended daily dietary allowance according to dietary reference intakes in Japanese adults (men 1.4 mg/day; women 1.2 mg/day). After adjusting for confounders, HRs for diabetic retinopathy in the 2nd, 3rd, and 4th quartile groups of vitamin B6 intake compared with the 1st quartile group were 1.17 (95% confidence interval 0.81-1.69, p = 0.403), 0.88 (0.58-1.34, p = 0.550), and 0.50 (0.30-0.85, p = 0.010), respectively.
Findings suggested that high vitamin B6 intake was associated with a lower incidence of diabetic retinopathy in Japanese with type 2 diabetes.
尽管维生素 B6 已被怀疑可预防糖尿病视网膜病变的进展，但基于纵向研究的证据在 2 型糖尿病患者中较为匮乏。本研究旨在探讨日本 2 型糖尿病患者维生素 B6 摄入量与糖尿病视网膜病变发病之间的关系。
该研究是对一项全国性 2 型糖尿病患者队列检查的一部分，参与者为年龄在 40-70 岁、糖化血红蛋白（HbA1c）≥48mmol/mol 的患者。在排除了根据食物组使用食物频率问卷进行膳食调查的非应答者后，共分析了 978 例患者。主要结局为 8 年糖尿病视网膜病变事件风险，Cox 回归分析根据维生素 B6 摄入量调整年龄、性别、体重指数、HbA1c、吸烟、能量摄入和其他混杂因素后，估计视网膜病变的风险比（HR）。
四分位区间内维生素 B6 摄入量的平均值范围为 1.1-1.6mg/天，半数参与者的维生素 B6 摄入量低于日本成年人膳食参考摄入量（男性 1.4mg/天；女性 1.2mg/天）推荐的每日膳食允许量。在校正混杂因素后，与第 1 四分位组相比，第 2、3 和 4 四分位组维生素 B6 摄入量的糖尿病视网膜病变 HR 分别为 1.17（95%置信区间 0.81-1.69，p=0.403）、0.88（0.58-1.34，p=0.550）和 0.50（0.30-0.85，p=0.010）。
研究结果表明，日本 2 型糖尿病患者维生素 B6 摄入量较高与糖尿病视网膜病变发病率较低相关。
