Meuer S C, Hauer M, Deusch K, Moebius U, Meyer zum Büschenfelde K H
Behring Inst Mitt. 1987 Jun(81):15-30.
Monoclonal antibodies capable of exerting agonistic functions toward surface receptors of human T lymphocytes are employed to study discrete signals involved in T cell activation via two differential pathways (antigen-induced and "alternative" pathway of T cell activation). The studies to be reported demonstrate that these two modes of T cell triggering are independent of each other since the respective cell surface molecules with which T cells interact in the initiation of activation and the requirements for monokines are clearly distinct. Moreover, preliminary investigations of various types of secondary immunodeficiencies suggest that immunologic dysfunction can be attributed to blockades at particular levels of the activation cascade.
能够对人T淋巴细胞表面受体发挥激动功能的单克隆抗体被用于研究通过两种不同途径（抗原诱导的和T细胞激活的“替代”途径）参与T细胞激活的离散信号。将要报道的研究表明，这两种T细胞触发模式彼此独立，因为T细胞在激活起始过程中与之相互作用的各自细胞表面分子以及对单核因子的需求明显不同。此外，对各种类型继发性免疫缺陷的初步研究表明，免疫功能障碍可归因于激活级联反应特定水平的阻断。
