微卫星不稳定高型肠腺癌亚型中 PD-L1 的表达模式。
PD-L1 Expression Patterns in Microsatellite Instability-High Intestinal Adenocarcinoma Subtypes.
机构信息
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Department of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.
出版信息
Am J Clin Pathol. 2019 Aug 1;152(3):384-391. doi: 10.1093/ajcp/aqz052.
OBJECTIVES
To investigate patterns of programmed death protein-1 (PD-L1) expression in microsatellite instability (MSI)-high intestinal carcinomas and correlate them with pathologic and molecular features.
METHODS
One hundred and fifteen MSI-high and 41 microsatellite stable carcinomas were included. Tumor sections were immunohistochemically labeled for PD-L1. The results were correlated with histologic subtypes, MSI, and BRAF status.
RESULTS
As expected, MSI status was associated with PD-L1 expression. Among 115 MSI-high tumors, PD-L1 expression was observed on tumor cells in 28 tumors and on tumor-associated inflammatory cells in 77 tumors. Medullary carcinoma demonstrated more frequent PD-L1 expression on tumor cells than mucinous and typical adenocarcinoma. PD-L1 expression was more frequent in medullary and typical adenocarcinoma than in mucinous adenocarcinoma based on combined positive scores. Tumors with more nucleotide shifts by PCR-based MSI testing were more likely to express PD-L1.
CONCLUSIONS
Expression of PD-L1 is different among different histologic subtypes of MSI-high intestinal carcinomas.
目的
研究微卫星不稳定（MSI）高的肠型癌中程序性死亡蛋白-1（PD-L1）的表达模式，并将其与病理和分子特征相关联。
方法
纳入 115 例 MSI 高和 41 例微卫星稳定的癌。肿瘤切片用 PD-L1 免疫组化标记。结果与组织学亚型、MSI 和 BRAF 状态相关联。
结果
MSI 状态与 PD-L1 表达相关，这是意料之中的。在 115 例 MSI 高的肿瘤中，28 例肿瘤细胞和 77 例肿瘤相关炎症细胞中观察到 PD-L1 表达。髓样癌的肿瘤细胞上 PD-L1 表达比黏液性和典型腺癌更频繁。基于联合阳性评分，髓样和典型腺癌的 PD-L1 表达比黏液腺癌更频繁。基于 PCR 的 MSI 检测中核苷酸移位越多的肿瘤更可能表达 PD-L1。
结论
MSI 高的肠型癌的不同组织学亚型中 PD-L1 的表达不同。
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