Department of Obstetrics and Gynecology, State Specialist Hospital, Akure, Nigeria.
Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospital Complex, Ilesha, Nigeria.
Int J Gynaecol Obstet. 2019 Sep;146(3):302-307. doi: 10.1002/ijgo.12877. Epub 2019 Jun 19.
To assess the severity of complications following misoprostol used to induce abortion compared with other methods among women admitted for postabortion complications.
A cross-sectional study of women who presented with complications of induced abortion at nine secondary and tertiary hospitals in South West Nigeria between April 1, 2013 and May 31, 2014. Face-to-face interviews were conducted and information on the current admission was extracted from patient records. Associations between abortion method used and severity of abortion complications were evaluated using χ and Fisher exact tests.
Of 522 women included in the study, 177 reported an induced abortion: 41 women (23.2%) had used misoprostol at the first attempt to induce abortion, whereas 79 (44.6%) women had undergone surgical abortion. Occurrence of fever (P=0.06), bleeding (P=0.3), and lower abdominal pain (P=0.32) was not significantly different between the misoprostol and surgical abortion/other methods groups. Severe complications were rare with misoprostol, but more common among women in the surgical abortion/other methods group. Maternal mortality occurred only among women in the surgical abortion/other methods group.
Use of misoprostol for induced abortion was associated with fewer complications and no maternal mortality compared with surgical abortion/other methods.
评估因人工流产而接受治疗的女性中，米索前列醇与其他方法相比导致的并发症严重程度。
这是一项在 2013 年 4 月 1 日至 2014 年 5 月 31 日期间，在尼日利亚西南部的 9 所二级和三级医院中，对因人工流产后并发症而入院的女性进行的横断面研究。采用面对面访谈的方式，从患者病历中提取当前入院信息。采用卡方检验和 Fisher 确切概率法评估所使用的流产方法与流产并发症严重程度之间的关联。
在纳入研究的 522 名女性中，有 177 名报告曾进行过人工流产：41 名（23.2%）女性首次使用米索前列醇诱导流产，而 79 名（44.6%）女性进行了手术流产。发热（P=0.06）、出血（P=0.3）和下腹痛（P=0.32）的发生率在米索前列醇组和手术流产/其他方法组之间无显著差异。米索前列醇组严重并发症罕见，但在手术流产/其他方法组中更为常见。仅在手术流产/其他方法组中发生了产妇死亡。
与手术流产/其他方法相比，米索前列醇用于人工流产与较少的并发症和无产妇死亡相关。
